XIAP Antibody

• Catalog number
  bs-1281R
• Price
  Please ask
• Size
  0.1ml

• Long name
  XIAP Primary Polyclonal Antibody
• Also known as
  XIAP PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  XIAP/BIRC4
• Specificity
  This is a highly specific antibody against XIAP/BIRC4.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  230-280/496
• Subcellular location
  Cytoplasm, Nucleus
• Source
  KLH conjugated synthetic peptide derived from mouse XIAP
• Gene ID number
  11798
• Swiss Prot
  Q60989
• Tested Applications
  WB, IHC-P, IF(IHC-P), IF(ICC)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin. Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation. Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its proteasomal degradation. Can also function as E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Regulates the BMP signaling pathway and the SMAD and MAP3K7/TAK1 dependent pathways leading to NF-kappa-B and JNK activation. Acts as an important regulator of innate immune signaling via regulation of Nodlike receptors (NLRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Acts as a positive regulator of Wnt signaling and ubiquitinates TLE1, TLE2, TLE3, TLE4 and AES. Ubiquitination of TLE3 results in inhibition of its interaction with TCF7L2/TCF4 thereby allowing efficient recruitment and binding of the transcriptional coactivator beta-catenin to TCF7L2/TCF4 that is required to initiate a Wnt-specific transcriptional program.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  Aipa; Api3; IAP3; MIHA; Birc4; ILP-1; 11115C2Rik; E3 ubiquitin-protein ligase XIAP; Baculoviral IAP repeat-containing protein 4; IAP homolog A; Inhibitor of apoptosis protein 3; IAP-3; mIAP-3; mIAP3; X-linked inhibitor of apoptosis protein; X-linked IAP; Xiap
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  XIAP  
• Gene symbol
  XIAP-AS1, XIAP
• Short name
  Anti-XIAP/BIRC4
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  XIAP Polyclonal Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  X-linked inhibitor of apoptosis, XIAP and IDBG-85142 and ENSG00000101966 and 331, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, nuclei

Gene info

• Identity
  HGNC:40078
• Gene
  XIAP-AS1
• Long gene name
  XIAP antisense RNA 1
• Synonyms gene name
  • XIAP antisense RNA 1 (non-protein coding)
• Locus
  Xq25
• Discovery year
  2011-07-28
• Classification
  • Antisense RNAs
• VEGA ID
  OTTHUMG00000022339

Gene info

• Identity
  HGNC:592
• Gene
  XIAP
• Long gene name
  X-linked inhibitor of apoptosis
• Synonyms gene
  • API3
  • BIRC4
• Synonyms gene name
  • baculoviral IAP repeat-containing 4
  • X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
• Synonyms
  • hILP
  • ILP-1
• Synonyms name
  • IAP-like protein 1
• GenBank acession
  • U45880
• Locus
  Xq25
• Discovery year
  1998-06-10
• Entrez gene record
  331
• Pubmed identfication
  • 8552191
  • 8654366
  • 15749826
• RefSeq identity
  • NM_001167
• Classification
  • Ring finger proteins
  • Baculoviral IAP repeat containing
• VEGA ID
  OTTHUMG00000022336
• Locus Specific Databases
  • BIRC4base: Mutation registry for X-linked lymphoproliferative syndrome
  • Global Variome shared LOVD
  • LRG_19

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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