anti-PAK2 Antibody

• Catalog number
  3885
• Price
  Please ask
• Size
  0.02 mg, 0.1 mg

• Gene info
  PAK2 Antibody: The p21-activated kinases (PAKs) are serine-threonine kinases that bind to the active forms of Cdc42 and Rac. They are divided into two groups, the first of which include PAK1, 2 and 3, and can be activated by Cdc42/Rac binding. Group 1 PAKs contain an autoinhibitory domain whose activity is regulated by Cdc42/Rac binding. The group 1 PAKs are known to be involved in cellular processes such as gene transcription, apoptosis, and cell morphology and motility. Much less is known about the second group, which includes PAK4, 5 and 6, and are not activated by Cdc42/Rac binding. Of the six PAK proteins, only PAK2 is ubiquitously expressed and cleaved by caspase-3. This cleavage removes the amino-terminal regulatory domain and generates a constitutively active kinase fragment. Recent experiments have shown that following cleavage, the active fragment is myristoylated and directed to the plasma membrane and membrane ruffles where it promotes cell death via increased signaling through the c-Jun N-terminal kinase pathway, but without compromising mitochondrial integrity.
• Gene names
  PAK2 Antibody: PAK65, PAKgammaGamma-PAK, PAK-2
• Antibodie s label
  unlabelled serum
• Purity
  PAK2 Antibody is affinity chromatography purified via peptide column.
• Ab raised in
  Rabbit
• Type
  Polyclonal
• Immunoglobulin
  IgG
• Antigen
  PAK2 antibody was made against a 14 amino acid synthetic peptide from near the carboxy terminus of human PAK2.
• Immuno application
  ELISA, Western Blot, immuno-histo-chemistry, immuno fluorescence
• Antibody advice
  PAK2 antibody can be used for the detection of PAK2 by Western blot at 0.5 - 1 ug/mL. Antibody can also be used for immunohistochemistry starting at 10 ug/mL. For immunofluorescence start at 20 ug/mL.
• Suspention pH azide
  PAK2 Antibody is supplied in PBS containing 0.02% sodium azide.
• Keep at
  PAK2 antibody can be stored at 4 grades C for three months and -20 grades C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Works with
  Human, Mouse, Rat
• Omim nr
  32483399
• Ncbi nr
  NP_002568
• Vial with antibody
  in solution
• Quantity per ml
  1 mg/mL
• NCBI GENE nr
  5062
• GENE symbol
  PAK2
• Antigene name
  p21 protein (Cdc42/Rac)-activated kinase 2
• Source
  Homo sapiens
• Protein nr
  Q13177
• Picture
• Pdf tech file
• More antibodies
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antibody for research use.
• Properties
  If you buy Antibodies supplied by proscience they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  PAK2  
• Gene symbol
  PAK2
• Short name
  anti-PAK2 Antibody
• Technique
  Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
• Alternative name
  Antibody toPAK2 (antibody to-)
• Alternative technique
  antibodies
• Alternative to gene target
  p21 protein (Cdc42/Rac)-activated kinase 2, PAK65 and PAKgamma, PAK2 and IDBG-71333 and ENSG00000180370 and 5062, transferase activity, nuclei, Pak2 and IDBG-153570 and ENSMUSG00000022781 and 224105, PAK2 and IDBG-634020 and ENSBTAG00000047856 and 513673

Gene info

• Identity
  HGNC:8591
• Gene
  PAK2
• Long gene name
  p21 (RAC1) activated kinase 2
• Synonyms gene name
  • p21 (CDKN1A)-activated kinase 2
  • p21 protein (Cdc42/Rac)-activated kinase 2
• Synonyms
  • PAK65
  • PAKgamma
• Synonyms name
  • S6/H4 kinase
• GenBank acession
  • U24153
• Locus
  3q29
• Discovery year
  1998-03-25
• Entrez gene record
  5062
• Pubmed identfication
  • 7744004
  • 7618083
• RefSeq identity
  • NM_002577
• VEGA ID
  OTTHUMG00000155534

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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