RABBIT ANTI PAK2 (C-TERMINAL)

• Catalog number
  MBS221479
• Price
  Please ask
• Size
  5x0.1 mg

• Products_type
  Antibody
• Products_short_name
  [PAK2]
• Other_names
  [serine/threonine-protein kinase PAK 2; Serine/threonine-protein kinase PAK 2; serine/threonine-protein kinase PAK 2; PAK-2; S6/H4 kinase; gamma-PAK; p21 (CDKN1A)-activated kinase 2; p21-activated kinase 2; p58; p21 protein (Cdc42/Rac)-activated kinase 2; Gamma-PAK; PAK65; S6/H4 kinase; p21-activated kinase 2; PAK-2; p58Cleaved into the following 2 chains:PAK-2p27; p27; PAK-2p34; p34Alternative name(s):C-t-PAK2]
• Products_gene_name
  [PAK2]
• Other_gene_names
  [PAK2; PAK2; PAK65; PAKgamma; PAK-2; p27; p34]
• Clonality
  Polyclonal
• Reactivity
  Mouse, Rat
• Specificity
  This item recognises p21-activated kinase-2 (PAK2), a ubiquitously expressed, 64kDa, serine/threonine protease found at higher levels in skeletal muscle, ovary, thymus and spleen. p21-activated kinases (PAKs) bind activated Cdc42 and Rac via a Cdc42/Rac interactive binding (CRIB) domain. Group 1 PAK kinases (PAK1, 2 and 3) regulate the activity of an adjacent conserved autoinhibitory domain and are associated with cellular processes, including cytoskeleton rearrangement, apoptosis and MAP kinase signalling. Group 2 PAKs (PAK4, 5, and 6) lack the autoinhibitory domain and are not activated by Cdc42/Rac binding. PAK2 has a cytostatic effect on cells and is activated in response to cellular stresses such hyperosmolarity, serum starvation, contact inhibition and DNA damage from radiation and chemicals. Unlike other PAKs, PAK2 can be activated by proteolytic cleavage to generate a constitutively active fragment, PAK2p34, which induces a cell death response. This induction is thought to be regulated by Rho GTPase-activating protein 10 which inhibits the protein kinase activity of PAK2p34 and causes it to localise to the perinuclear region instead of the nucleus. PAK2 may also play a role in X-linked mental retardation.
• Form
  Purified Purified IgG - liquid
• Concentration
  IgG concentration 1.0mg/ml
• Storage_stability
  Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
• Tested_application
  Immunohistology Paraffin*, Western Blot (WB)
• Description
  This antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
• About
  Rabbits are used for polyclonal antibody production by MyBioSource. Rabbit antibodies are very stable and can be stored for several days at room temperature. MyBioSource adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
• Latin name
  Oryctolagus cuniculus

• Gene target
  PAK2  
• Gene symbol
  PAK2
• Short name
  RABBIT ANTI PAK2 (C-TERMINAL)
• Technique
  Rabbit, anti, antibody to
• Host
  Rabbit, Rabbits
• Isotype
  IgG
• Alternative name
  production species: rabbit antibody to p21 protein (Cdc42/Rac)-activated kinase 2 (C-TERMINAL)
• Alternative technique
  rabbit-anti, antibodies
• Alternative to gene target
  p21 protein (Cdc42/Rac)-activated kinase 2, PAK65 and PAKgamma, PAK2 and IDBG-71333 and ENSG00000180370 and 5062, transferase activity, nuclei, Pak2 and IDBG-153570 and ENSMUSG00000022781 and 224105, PAK2 and IDBG-634020 and ENSBTAG00000047856 and 513673

Gene info

• Identity
  HGNC:8591
• Gene
  PAK2
• Long gene name
  p21 (RAC1) activated kinase 2
• Synonyms gene name
  • p21 (CDKN1A)-activated kinase 2
  • p21 protein (Cdc42/Rac)-activated kinase 2
• Synonyms
  • PAK65
  • PAKgamma
• Synonyms name
  • S6/H4 kinase
• GenBank acession
  • U24153
• Locus
  3q29
• Discovery year
  1998-03-25
• Entrez gene record
  5062
• Pubmed identfication
  • 7744004
  • 7618083
• RefSeq identity
  • NM_002577
• VEGA ID
  OTTHUMG00000155534

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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