Rat anti Forssman antigen
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Catalog numberMUB0610S
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Price:
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Size1 mL
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CategoryPrimary Antibodies
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Long descriptionThe Forssman glycolipid is a glycosylceramide possessing a neutral pentasaccharide head group, referred to as the Forssman antigen (Fa) and is a member of the globoseries glycolipid family. Fa has been identified in a number of mammals and exhibits heterogeneity with respect to developmental and cell-type expression among species. Some studies have reported the presence of the Fa in certain Human embryonic and tumor cells. The majority of Human individuals have undetectable levels of Fa. Gastric and colonic tumors from Fa-negative patients, however, contained relatively high levels of Fa. Moreover, compared with normal lung tissue, many lung cancers contained elevated levels of Fa. These observations arouse interest in Fa for a possible role as a Human tumor antigen.
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Antibody come fromThe antibody 117C9 is a Rat anti-Forrsman glycosphingolipid (FGL) antibody derived by fusing Mouse myeloma cells with spleen cells from a Rat immunized with Mouse mammary tumors.
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Other descriptionEach vial contains 1ml of culture supernatant of monoclonal antibody containing 0.09% sodium azide.
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Clone117C9
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Antigen antibody binding interactionRat anti Forssman antigen Antibody
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Antibody is raised inRat
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Antibody s reacts withMouse
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Antibody s reacts with these speciesThis antibody doesn't cross react with other species
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Antibody s specificityClone 33B12 and 117C9 detect overlapping epitopes on the Forssman glycolipid hapten (GalNA1- c3aG alNAcD1 -3GalaI-4GalB1-4GlcBl-lCer). Clone 117C9 recognizes the internal sugar sequence GalNAqYlBGal. The 117C9 antibody does not react exclusively with the Forssman antigen. In.a lipid extract fractionated by Folch partition of Mouse mammary tumors the antibody also detects other glycolipid.
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Research interestCancer,Immunology
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ApplicationImmunohistochemistry (frozen)
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Antibody s suited for117C92 is useful for immuohistochemistry on frozen sections. Optimal antibody dilution should be determined by titration.
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StorageStore at 4°C, or in small aliquots at -20°C.
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Relevant referencesJ Immunol. 1986 Aug 15;137(4):1264-9, "Monoclonal antibodies detecting different epitopes on the Forssman glycolipid hapten". Sonnenberg A, van Balen P, Hengeveld T, Kolvenbag GJ, Van Hoeven RP, Hilgers J.
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Protein numberQ8VI38
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WarningsThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This product contains sodium azide. To prevent formation of toxic vapors, do not mix with strong acidic solutions. To prevent formation of potentially explosive metallic azides in metal plumbing, always wash into drain with copious quantities of water. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
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DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided. Antigens are peptides or recombinant or native dependent on the production method.
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AboutRats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
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Latin nameRattus norvegicus
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Gene target
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Gene symbolGBGT1, PHF6
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Short nameanti Forssman antigen
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Techniqueantigen, anti, antibody to, antigenes
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HostRat
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IsotypeIgM
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Labelunlabeled
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SpeciesRat, Rats
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Alternative nameRat antibody to Forssman protein
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Alternative techniqueantigenes, antibodies
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Gene info
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Identity
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Gene
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Long gene namegloboside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2004-05-17
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Blood group antigens
- Glycosyltransferase family 6
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namePHD finger protein 6
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Synonyms gene
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Synonyms gene name
- Borjeson-Forssman-Lehmann syndrome
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year2002-02-28
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- PHD finger proteins
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data