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Rat anti Forssman antigen

  • Catalog number
    MUB0609P
  • Product name
    Rat anti Forssman antigen
  • Size
    0,1 mg
  • Category
    Primary Antibodies
  • Long description
    The Forssman glycolipid is a glycosylceramide possessing a neutral pentasaccharide head group, referred to as the Forssman antigen (Fa) and is a member of the globoseries glycolipid family. Fa has been identified in a number of mammals and exhibits heterogeneity with respect to developmental and cell-type expression among species. Some studies have reported the presence of the Fa in certain Human embryonic and tumor cells.The majority of Human individuals have undetectable levels of Fa.Gastric and colonic tumors from Fa-negative patients, however, contained relatively high levels of Fa. Moreover, compared with normal lung tissue, many lung cancers contained elevated levels of Fa. These observations arouse interest in Fa for a possible role as a Human tumor antigen.
  • Antibody come from
    The antibody 33B12 is a Rat anti-Forrsman glycosphingolipid (FGL) antibody derived by fusing Mouse myeloma cells with spleen cells from a Rat immunized with Mouse mammary tumors.
  • Other description
    Each vial contains 100 ul 1 mg/ml purified monoclonal antibody in PBS containing 0.09% sodium azide.
  • Clone
    33B12
  • Isotype
    IgG2c
  • Antigen antibody binding interaction
    Rat anti Forssman antigen Antibody
  • Antibody is raised in
    Rat
  • Antibody s reacts with
    Mouse
  • Antibody s reacts with these species
    This antibody doesn't cross react with other species
  • Label
    unlabeled
  • Antibody s specificity
    Clone 33B12 and 117C9 detect overlapping epitopes on the Forssman glycolipid hapten (GalNA1- c3aG alNAcD1 -3GalaI-4GalB1-4GlcBl-lCer). Clone 33B12 reacts with the terminal sugar sequence GalNAcd-3GalNAc and is specific for Forssman antigen.
  • Research interest
    Cancer,Immunology
  • Application
    Immunohistochemistry (frozen)
  • Antibody s suited for
    33B12 is useful for immubohistochemistry on frozen sections. Optimal antibody dilution should be determined by titration.
  • Storage
    Store at 4°C, or in small aliquots at -20°C.
  • Relevant references
    Sonnenberg A, van Balen P, Hengeveld T, Kolvenbag GJ, Van Hoeven RP, Hilgers J., Monoclonal antibodies detecting different epitopes on the Forssman glycolipid hapten. J Immunol. 1986 Aug 15;137(4):1264-9
  • Protein number
    Q8VI38
  • Warnings
    This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This product contains sodium azide. To prevent formation of toxic vapors, do not mix with strong acidic solutions. To prevent formation of potentially explosive metallic azides in metal plumbing, always wash into drain with copious quantities of water. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
  • Antibody s link
    Antibody_s_link
  • Gene target
    Forssman
    • Gene info
    Locus Specific Databases:LRG_826
    Gene info
    Locus Specific Databases:LRG_629
  • Gene symbol
    GBGT1, PHF6
  • Host
    Rat
  • isotype filter
    • IgG2c
  • Short name
    anti Forssman antigen
  • label filter
    • unlabeled
  • technique filter
    • antigen
    • anti
  • Technique
    antigen, anti, antibody to, antigenes
  • Alternative technique
    antigenes, antibodies