Rabbit anti Sphingosine 1-Phosphate Phosphatase 2
-
Catalog numberX1637P
-
PricePlease ask
-
Size10MinibLots
-
-
CategoryPrimary Antibodies
-
Long descriptionSphingosine 1-phosphate (S1P) is a highly bioactive lipid that has a myriad of biological effects both intracellularly as a second messenger and extracellularly by binding to the S1P(1-5)/G-protein-coupled receptors of the endothelial differentiation gene family. Intracellularly, at least two enzymes, sphingosine kinase (1 and 2) and S1P phosphatase, regulate the activity of S1P by governing the phosphorylation of S1P. SPPase2 is localized to the endoplasmic reticulum. The enzymatic activity and localization of SPPase2 are similar to SPPase1. The tissue expression of SPPase2 was different from that of SPPase1. SPPase2 is an important member of the SPPase family which play a role in attenuating intracellular S1P signaling.
-
Antibody come fromRecombinant enyzme produced in E. coli
-
Other descriptionProvided in 25 mM Tris-HCl, 75 mM NaCl, pH 8.0, 0.05% Tween, 5 mM DTT and 50% glycerol. Antigen Immunoaffiinity Purification
-
ClonePolyclonal
-
Antigen antibody binding interactionRabbit anti Sphingosine 1-Phosphate Phosphatase 2 Antibody
-
Antibody is raised inRabbit
-
Antibody s reacts withHuman
-
Antibody s reacts with these speciesThis antibody doesn't cross react with other species
-
Antibody s specificityNo Data Available
-
ApplicationWestern Blot
-
Antibody s suited for3.3 pmole/min/µg of enzyme; Detemined using DiFMUP; Reaction conditions: 100 µM DiFMUP, 10 min incubation at 30¼C, 5 µg enzyme.
-
Storage-80ºC
-
Relevant references[1] Cates C.A., Michael R.L., Stayrook K.R., Harvey K.A., Burke Y.D., Randall S.K., Crowell P.L., Crowell D.N.; Prenylation of oncogenic human PTP(CAAX) protein tyrosine phosphatases.; Cancer Lett. 110:49-55(1996)._x000B_[2] Peng Y., Genin A., Spinner N.B., Diamond R.H., Taub R.; The gene encoding human nuclear protein tyrosine phosphatase, PRL-1. Cloning, chromosomal localization, and identification of an intron enhancer.; J. Biol. Chem. 273:17286-17295(1998)._x000B_[3] Gjorloff-Wingren A, Saxena M, Han S, Wang X, Alonso A, Renedo M, Oh P, Williams S, Schnitzer J, Mustelin T. Subcellular localization of intracellular protein tyrosine phosphatases in T cells._x000B_Eur J Immunol. 2000 Aug;30(8):2412-21. _x000B_[4] Yarovinsky TO, Rickman DW, Diamond RH, Taub R, Hageman GS, Bowes Rickman C._x000B_Expression of the protein tyrosine phosphatase, phosphatase of regenerating liver 1, in the outer segments of primate cone photoreceptors. Brain Res Mol Brain Res. 2000 Apr 14;77(1):95-103. _x000B_[5] Carter DA. Expression of a novel rat protein tyrosine phosphatase gene. Biochim Biophys Acta. 1998 Nov 8;1442(2-3):405-8. _x000B_[6] Zeng Q, Hong W, Tan YH. Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1. Biochem Biophys Res Commun. 1998 Mar 17;244(2):421-7. _x000B_[7] Cates CA, Michael RL, Stayrook KR, Harvey KA, Burke YD, Randall SK, Crowell PL, Crowell DN Prenylation of oncogenic human PTP(CAAX) protein tyrosine phosphatases. Cancer Lett. 1996 Dec 20;110(1-2):49-55. _x000B_[8] Takano S, Fukuyama H, Fukumoto M, Kimura J, Xue JH, Ohashi H, Fujita J. PRL-1, a protein tyrosine phosphatase, is expressed in neurons and oligodendrocytes in the brain and induced in the cerebral cortex following transient forebrain ischemia. Brain Res Mol Brain Res. 1996 Aug;40(1):105-15. _x000B_
-
Protein numbersee ncbi
-
WarningsThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
-
DescriptionThis antibody needs to be stored at + 4°C in a fridge short term in a concentrated dilution. Freeze thaw will destroy a percentage in every cycle and should be avoided.
-
AboutRabbits are used for polyclonal antibody production by nordc. Rabbit antibodies are very stable and can be stored for several days at room temperature. nordc adds sodium azide and glycerol to enhance the stability of the rabbit polyclonal antibodies. Anti-human, anti mouse antibodies to highly immunogenic selected peptide sequences are" monoclonal like" since the epitope to which they are directed is less than 35 amino acids long.
-
Latin nameOryctolagus cuniculus
-
Gene target
-
Gene symbolSGPP2
-
Short nameRabbit anti Sphingosine 1-Phosphate Phosphatase 2
-
TechniqueRabbit, anti, antibody to
-
HostRabbit, Rabbits
-
Isotypenot specified
-
Labelunlabeled
-
Alternative nameproduction species: rabbit antibody to Sphingosine 1-Phosphate Phosphatase 2
-
Alternative techniquerabbit-anti, antibodies
-
Gene info
-
Identity
-
Gene
-
Long gene namesphingosine-1-phosphate phosphatase 2
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2003-02-12
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Sphingosine-1-phosphate phosphatases
-
VEGA ID
MeSH Data
-
Name
-
ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
-
Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
-
Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data