PROX1 Antibody

• Catalog number
  F47896-0.4ML
• Price
  Please ask
• Size
  0.4 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  PROX1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens) ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, ELISA
• Recommended dilutions
  Western blot: 1:1000
• Notes
  Titration of the PROX1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This PROX1 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q92786
• Purity
  Antigen affinity
• Description
  The expression pattern of Prox1 suggests that it has a role in a variety of embryonic tissues, including lens. Prox mRNA is present in many different human tissues with lens demonstrating the highest level. Homozygous Prox1-null mice die at midgestation from multiple developmental defects, and a targeted effect on lens development has been reported. Prox1 inactivation caused abnormal cellular proliferation, downregulated expression of the cell cycle inhibitors Cdkn1b and Cdkn1c, misexpression of E-cadherin, and excessive apoptosis. Consequently, mutant lens cells failed to polarize and elongate properly, resulting in a hollow lens. Prox1 is expressed in a subpopulation of endothelial cells that by budding and sprouting give rise to the lymphatic system. Prox1 appears to be a specific and required regulator of the development of the lymphatic system. Prox1 also has been documented to be required for hepatocyte migration in the mouse. Loss of Prox1 results in a smaller liver with a reduced population of clustered hepatocytes. The homeodomain protein Prox1 regulates the egress of progenitor cells from the cell cycle in the embryonic mouse retina. Cells lacking Prox1 are less likely to stop dividing, and ectopic expression of Prox1 forces progenitor cells to exit the cell cycle. Prox1 acts as a key participant in progenitor-cell proliferation and cell-fate determination in the vertebrate retina.
• Immunogen
  A portion of amino acids 175-206 from the human protein was used as the immunogen for this PROX1 antibody.
• Storage
  Aliquot the PROX1 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  PROX1  
• Gene symbol
  PROX1, PROX1-AS1
• Short name
  Anti-PROX1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to PROX1
• Alternative technique
  antibodies
• Alternative to gene target
  prospero homeobox 1, PROX1 and IDBG-106631 and ENSG00000117707 and 5629, LBD domain binding, nuclei, Prox1 and IDBG-208536 and ENSMUSG00000010175 and 19130, PROX1 and IDBG-638014 and ENSBTAG00000010978 and 515324

Gene info

• Identity
  HGNC:9459
• Gene
  PROX1
• Long gene name
  prospero homeobox 1
• Synonyms gene name
  • prospero-related homeobox 1
• GenBank acession
  • U44060
• Locus
  1q32.3
• Discovery year
  1998-05-18
• Entrez gene record
  5629
• Pubmed identfication
  • 8812486
• RefSeq identity
  • NM_002763
• Classification
  • PROS class homeoboxes
• VEGA ID
  OTTHUMG00000036946

Gene info

• Identity
  HGNC:43656
• Gene
  PROX1-AS1
• Long gene name
  PROX1 antisense RNA 1
• Synonyms gene name
  • PROX1 antisense RNA 1 (non-protein coding)
• GenBank acession
  • AK092251
• Locus
  1q32.3
• Discovery year
  2012-01-23
• Entrez gene record
  100505832
• RefSeq identity
  • NR_037850
• Classification
  • Antisense RNAs

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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