PROX1 Antibody

• Catalog number
  F47894-0.4ML
• Price
  Please ask
• Size
  0.4 ml

• Category
  Antibody
• Concentration
  In 1X PBS, pH 7.4, with 0.09% sodium azide
• Form
  Purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  PROX1
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IF, ELISA
• Recommended dilutions
  Western blot: 1:500,Immunofluorescence: 1:10-1:50
• Notes
  Titration of the PROX1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This PROX1 antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  Q92786
• Purity
  Purified
• Description
  The expression pattern of Prox1 suggests that it has a role in a variety of embryonic tissues, including lens. Prox mRNA is present in many different human tissues with lens demonstrating the highest level. Homozygous Prox1-null mice die at midgestation from multiple developmental defects, and a targeted effect on lens development has been reported. Prox1 inactivation caused abnormal cellular proliferation, downregulated expression of the cell cycle inhibitors Cdkn1b and Cdkn1c, misexpression of E-cadherin, and excessive apoptosis. Consequently, mutant lens cells failed to polarize and elongate properly, resulting in a hollow lens.
• Immunogen
  A portion of amino acids 492-522 from the human protein was used as the immunogen for this PROX1 antibody.
• Storage
  Aliquot the PROX1 antibody and store frozen at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  PROX1  
• Gene symbol
  PROX1, PROX1-AS1
• Short name
  Anti-PROX1
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit Ig
• Alternative name
  Antibodies to PROX1
• Alternative technique
  antibodies
• Alternative to gene target
  prospero homeobox 1, PROX1 and IDBG-106631 and ENSG00000117707 and 5629, LBD domain binding, nuclei, Prox1 and IDBG-208536 and ENSMUSG00000010175 and 19130, PROX1 and IDBG-638014 and ENSBTAG00000010978 and 515324

Gene info

• Identity
  HGNC:9459
• Gene
  PROX1
• Long gene name
  prospero homeobox 1
• Synonyms gene name
  • prospero-related homeobox 1
• GenBank acession
  • U44060
• Locus
  1q32.3
• Discovery year
  1998-05-18
• Entrez gene record
  5629
• Pubmed identfication
  • 8812486
• RefSeq identity
  • NM_002763
• Classification
  • PROS class homeoboxes
• VEGA ID
  OTTHUMG00000036946

Gene info

• Identity
  HGNC:43656
• Gene
  PROX1-AS1
• Long gene name
  PROX1 antisense RNA 1
• Synonyms gene name
  • PROX1 antisense RNA 1 (non-protein coding)
• GenBank acession
  • AK092251
• Locus
  1q32.3
• Discovery year
  2012-01-23
• Entrez gene record
  100505832
• RefSeq identity
  • NR_037850
• Classification
  • Antisense RNAs

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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