CAR Antibody Coxsackie Adenovirus Receptor
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Catalog numberR30950
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PricePlease ask
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Size0.1mg
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CategoryAntibody
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Concentration0.5mg/ml if reconstituted with 0.2ml sterile DI water
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FormAntigen affinity purified
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ConjugationUnconjugated
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ClonePolyclonal antibody
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Recognised antigenCAR Coxsackie Adenovirus Receptor
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Host animalRabbit (Oryctolagus cuniculus)
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ClonalityPolyclonal (rabbit origin)
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Species reactivityHuman (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
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Tested applicationsWB
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Recommended dilutionsWestern blot: 0.5-1ug/ml
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NotesThe stated application concentrations are suggested starting amounts. Titration of the CAR antibody may be required due to differences in protocols and secondary/substrate sensitivity.
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Intented useThis CAR antibodyis to be used only for research purposes and not for diagnostics..
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UniprotP78310
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PurityAntigen affinity
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DescriptionCoxsackie virus and adenovirus receptor is a protein that in humans is encoded by the CXADR gene, also known as CAR, CVB3-binding protein, and Coxsackievirus B-adenovirus receptor. The cDNA encodes a predicted 365-amino acid polypeptide that contains a single transmembrane domain and is a member of the immunoglobulin superfamily. By Northern blot analysis, the highest expression of 1.4-kb and 6-kb transcripts are in pancreas, brain, heart, small intestine, testis, and prostate, lower expression in liver and lung, and no expression in kidney, placenta, peripheral blood leukocytes, thymus, and spleen. In comparison, mouse CAR showed highest expression in liver, and lower levels in kidney, heart, lung, and brain. The protein encoded by this gene is a type I membrane receptor for group B coxsackie viruses and subgroup C adenoviruses. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. CAR is strongly expressed in the developing central nervous system. It functions as a homophilic and also as a heterophilic cell adhesion molecule through its interactions with extracellular matrix glycoproteins , such as: fibronectin, agrin, laminin-1 and tenascin-R.
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ImmunogenAn amino acid sequence from the C-terminus of human Coxsackie Adenovirus Receptor (YSKTQYNQVPSEDFER) was used as the immunogen for this CAR antibody (100% homologous in human, mouse and rat).
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StorageAfter reconstitution, the CAR antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
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PropertiesIf you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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Additional descriptionThe receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
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French translationanticorps
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Gene target
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Gene symbolCXADR, CXADRP1, NR1I3, SPG7
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Short nameAnti-CAR Coxsackie Adenovirus Receptor
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TechniqueAntibody, antibodies against human proteins, antibodies for
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IsotypeRabbit IgG
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Alternative nameAntibodies to CAR Coxsackie Adenovirus Receptor
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Alternative techniqueantibodies
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Virusadenovirus, coxsackie
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Gene info
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Identity
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Gene
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Long gene nameCXADR Ig-like cell adhesion molecule
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Synonyms gene name
- coxsackie virus and adenovirus receptor
- CXADR, Ig-like cell adhesion molecule
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Synonyms
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GenBank acession
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Locus
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Discovery year1998-03-24
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Entrez gene record
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Pubmed identfication
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Classification
- IgCAM CXADR-related subfamily
- V-set domain containing
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameCXADR pseudogene 1
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Synonyms gene name
- coxsackie virus and adenovirus receptor pseudogene 1
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Synonyms
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Locus
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Discovery year2008-01-31
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Entrez gene record
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namenuclear receptor subfamily 1 group I member 3
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Synonyms gene name
- nuclear receptor subfamily 1, group I, member 3
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1999-09-23
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Pubmed identfication
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Classification
- Nuclear receptor subfamily 1 group I
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameSPG7 matrix AAA peptidase subunit, paraplegin
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Synonyms gene
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Synonyms gene name
- cell matrix adhesion regulator
- spastic paraplegia 7 (pure and complicated autosomal recessive)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1998-06-25
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- AAA ATPases
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
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Tree numbers
- E05.196.401.143
- E05.301.300.096
- E05.478.566.320.200
- E05.601.262
- E05.601.470.320.200
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Qualifiersethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
