ATP7B Antibody

• Catalog number
  R31386
• Price
  Please ask
• Size
  0.1mg

• Category
  Antibody
• Concentration
  0.5mg/ml if reconstituted with 0.2ml sterile DI water
• Form
  Antigen affinity purified
• Conjugation
  Unconjugated
• Clone
  Polyclonal antibody
• Recognised antigen
  ATP7B
• Host animal
  Rabbit (Oryctolagus cuniculus)
• Clonality
  Polyclonal (rabbit origin)
• Species reactivity
  Human (Homo sapiens), Mouse (Mus musculus), Rat ; Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur.
• Tested applications
  WB, IHC-P
• Recommended dilutions
  Western blot: 0.5-1ug/ml,IHC (Paraffin): 0.5-1ug/ml
• Notes
  The stated application concentrations are suggested starting amounts. Titration of the ATP7B antibody may be required due to differences in protocols and secondary/substrate sensitivity.
• Intented use
  This ATP7B antibodyis to be used only for research purposes and not for diagnostics..
• Uniprot
  P35670
• Purity
  Antigen affinity
• Description
  ATPase, Cu++ transporting, beta polypeptide, also called ATP7B, is an ATPase that transports copper. This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least two putative copper-binding sites. ATP7B is mapped to 13q14.3. The protein functions as a monomer, exporting copper out of the cells. When copper levels are in excess, ATP7B redistributes to a vesicular compartment near the biliary canalicular membranes for elimination of excess copper into bile, and it is transported along liver cell microtubules via interaction with the p62 Dynactin subunit.
• Immunogen
  An amino acid sequence from the C-terminus of human ATP7B (DKWSLLLNGRDEEQYI) was used as the immunogen for this ATP7B antibody.
• Storage
  After reconstitution, the ATP7B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20 deg. Celcius or lower. Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity. Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized. Avoid repeated freezing and thawing.
• Properties
  If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  ATP7B  
• Gene symbol
  ATP7B
• Short name
  Anti-ATP7B
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Isotype
  Rabbit IgG
• Alternative name
  Antibodies to ATP7B
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:870
• Gene
  ATP7B
• Long gene name
  ATPase copper transporting beta
• Synonyms gene
  • WND
• Synonyms gene name
  • ATPase, Cu++ transporting, beta polypeptide (Wilson disease)
  • ATPase, Cu++ transporting, beta polypeptide
• Synonyms name
  • Wilson disease
  • copper pump 2
  • copper-transporting ATPase 2
• GenBank acession
  • U11700
• Locus
  13q14.3
• Discovery year
  1986-01-01
• Entrez gene record
  540
• Pubmed identfication
  • 8298641
  • 8298639
• RefSeq identity
  • NM_000053
• Classification
  • ATPase copper transporting
• VEGA ID
  OTTHUMG00000017406
• Locus Specific Databases
  • Wilson Disease Mutation Database
  • UMD Locus Specific Databases

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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