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Target antigen
ATP7b
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Clonality
Polyclonal antibody
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Clone
Polyclonal antibody
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Raised in
rabbit
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Type of the antibody
IgG polyclonal antibody
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Product form
freeze-dried
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Reacts with species
human, rat Predicted to work with: mouse
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Analyses
WB,IHC-P
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Immunogen
A synthetic peptide corresponding to a sequence at the C-terminus of human ATP7b(1451-1465aa DKWSLLLNGRDEEQYI), different from the related mouse and rat sequences by three amino acids.
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Product configuration
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
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Purification
Immunogen affinity purified.
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Solubilization
The powdered antibody should be dissolved in 0.2 ml of distilled water to achieve final concentration of 500ug/ml
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Storage condtions
Keep the ATP7b Antibodyat minus twenty degrees Celsius for 1 year. The ready-to-use solutions can be stored at four degrees Celsius for a month. Our specialsits recommend to freeze the aliquotes at minus twenty degrees Celsius for long-term application. Multiple procedures of freezing and thawing influence the specifity and reactivity of the antibody in a negative way.
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Tips
The ATP7b Antibody did not cross-reacted with other proteins during the test procedures. This antobdy is intended to be used for research analyses and it is not applicale for in vitro diagnostics.
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Background
ATPase, Cu++ transporting, beta polypeptide(Wilson disease) protein, also called ATP7B, is an ATPase that transports copper. This gene is a member of the P-type cation transport ATPase family and encodes a protein with several membrane-spanning domains, an ATPase consensus sequence, a hinge domain, a phosphorylation site, and at least two putative copper-binding sites. ATP7B is mapped to 13q14.3. This protein functions as a monomer, exporting copper out of the cells. When copper levels are in excess, ATP7B redistributes to a vesicular compartment near the biliary canalicular membranes for elimination of excess copper into bile, and it is transported along liver cell microtubules via interaction with the p62 dynactin subunit.
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Related articles
1. "Entrez Gene: ATP7B ATPase, Cu++ transporting, beta polypeptide" 2. Lim, C. M., Cater, M. A., Mercer, J. F. B., La Fontaine, S. Copper-dependent interaction of dynactin subunit p62 with the N terminus of ATP7B but not ATP7A. J. Biol. Chem. 281: 14006-14014, 2006.
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Gene Name
ATP7B
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Protein Name
Copper-transporting ATPase 2
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Gene Full Name
ATPase, Cu++ transporting, beta polypeptide
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Synonyms
ATP7B antibody|ATPase Cu++ transporting beta polypeptide antibody|ATPase Cu++ transporting beta polypeptide antibody|ATPase, Cu(2+) transporting, beta polypeptide antibody|ATPase, Cu++ transporting, beta polypeptide antibody|Copper pump 2 antibody|Copper transporting ATPase 2 antibody|PWD antibody|Toxic milk antibody|tx antibody|WC1 antibody|WD antibody|Wilson disease associated protein antibody|Wilson disease-associated protein antibody|WND antibody|WND/140 kDa antibody
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Uniprot ID
P35670
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Properties
If you buy Antibodies supplied by boster they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
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French translation
anticorps
