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Products_type
Antibody
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Products_short_name
[Platelet Derived Growth Factor Receptor beta]
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Products_name_syn
[Anti -Platelet Derived Growth Factor Receptor beta, phosphorylated (Tyr751) (PDGFRb)]
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Other_names
[platelet-derived growth factor receptor beta]
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Clonality
Polyclonal
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Reactivity
Human, Mouse, Rat
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Specificity
Detects endogenous levels of PDGF receptor beta only when phosphorylated at Tyr751 (190kD). Does not crossreact with other tyrosine-phosphorylated proteins. Species Crossreactivity: Human, mouse, rat.
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Purity
Affinity Purified Purified by Protein A and immunoaffinity chromatography.
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Form
Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, BSA, 0.02% sodium azide, 50% glycerol.
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Storage_stability
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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Tested_application
Western Blot (WB), Flow Cytometry (FC/FACS)
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Description
Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells. Platelets, also called thrombocytes or cloth cells in blood and are needed to stop bleeding by clumping and clotting the blood the vessels when the an injury occurs. Teh bone marrow will produce the platelets that have no nucleus. Platelates are unique to mammals, the are curved shaped 1900nm to 3100 nm large nucleus free clothing structures. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.
