LSD1, NT (Lysine-specific Histone Demethylase 1A, Amine Oxidase Flavin Containing Domain Protein 2, BRAF35-HDAC Complex Protein BHC110, AOF2, KIAA0601, KDM1)[LSD1]

• Catalog number
  MBS627873
• Price
  Please ask
• Size
  NA

• Products_type
  Antibody
• Reactivity
  Human, Mouse
• Gene
  Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, was belonged to the superfamily of the Flavin adenine dinucleotide (FAD)-dependent amine oxidases. LSD1 specifically demethylates mono- or dimethylated dimethylated histone H3 lysine4 (H3K4) and H3 lysine 9 (H3K9) via a redox process. Recently evidences showed that LSD1 played an important role in a broad spectrum of biological processes, including cell proliferation, adipogenesis, spermatogenesis, chromosome segregation and embryonic development. Furthermore, LSD1 also could promote progress of tumor by inhibiting the tumor suppressor activity of p53. To date, as a potential drug for discovering anti-tumor drugs, the medical significance of LSD1 inhibitors have been greatly appreciated. Here, we reviewed the remarkable progress being made in understanding of LSD1, mainly on its structure, basic function and medical application in tumor therapy.

• Gene target
  LSD1   Lysine-specific   Histone   Demethylase   Amine   Oxidase   Flavin   Domain   Protein   BRAF35-HDAC   Complex   Protein   BHC110   AOF2   KIAA0601   KDM1   [LSD1]  
• Gene symbol
  KDM1A, HDAC4, HDAC9, HMG20B
• Short name
  LSD1, NT (Lysine-specific Histone Demethylase 1A, Amine Oxidase Flavin Domain Protein 2, BRAF35-HDAC Complex Protein BHC110, AOF2, KIAA0601, KDM1)[LSD1]
• Host
  Rabbit
• Alternative name
  LSD1, NT (Lysine-specific Histone Demethylase 1A, Amine Oxidase Flavin Containing Domain Protein 2, BRAF35-HDAC aggregate Protein BHC110, AOF2, KIAA0601, KDM1)[LSD1]

Gene info

• Identity
  HGNC:29079
• Gene
  KDM1A
• Long gene name
  lysine demethylase 1A
• Synonyms gene
  • AOF2
  • KDM1
• Synonyms gene name
  • amine oxidase (flavin containing) domain 2
  • lysine (K)-specific demethylase 1
• Synonyms
  • KIAA0601
  • BHC110
  • LSD1
• Synonyms name
  • Lysine-specific histone demethylase 1A
• GenBank acession
  • AL031428
• Locus
  1p36.12
• Discovery year
  2004-02-26
• Entrez gene record
  23028
• Pubmed identfication
  • 9628581
  • 12493763
• RefSeq identity
  • NM_015013
• Classification
  • MicroRNA protein coding host genes
  • Lysine demethylases
• VEGA ID
  OTTHUMG00000003220

Gene info

• Identity
  HGNC:14063
• Gene
  HDAC4
• Long gene name
  histone deacetylase 4
• Synonyms gene
  • BDMR
• Synonyms gene name
  • brachydactyly-mental retardation syndrome
• Synonyms
  • KIAA0288
  • HDAC-A
  • HDACA
  • HD4
  • HA6116
  • HDAC-4
• GenBank acession
  • AB006626
• Locus
  2q37.3
• Discovery year
  2000-11-28
• Entrez gene record
  9759
• Pubmed identfication
  • 10206986
  • 10220385
  • 20691407
• RefSeq identity
  • NM_006037
• Classification
  • Histone deacetylases, class IIA
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000133344

Gene info

• Identity
  HGNC:14065
• Gene
  HDAC9
• Long gene name
  histone deacetylase 9
• Synonyms
  • KIAA0744
  • HDAC
  • MITR
  • HD7
  • HDAC7B
• GenBank acession
  • AF124924
• Locus
  7p21.1
• Discovery year
  2002-09-06
• Entrez gene record
  9734
• Pubmed identfication
  • 10523670
  • 10487760
• Classification
  • Histone deacetylases, class IIA
• VEGA ID
  OTTHUMG00000152487

Gene info

• Identity
  HGNC:5002
• Gene
  HMG20B
• Long gene name
  high mobility group 20B
• Synonyms gene name
  • high-mobility group 20B
• Synonyms
  • SOXL
  • HMGX2
  • BRAF35
  • SMARCE1r
  • BRAF25
  • HMGXB2
• Synonyms name
  • HMG box domain containing 2
• GenBank acession
  • BC003505
• Locus
  19p13.3
• Discovery year
  1999-06-11
• Entrez gene record
  10362
• Pubmed identfication
  • 10773667
• RefSeq identity
  • NM_006339
• Classification
  • Non-canonical high mobility group
• VEGA ID
  OTTHUMG00000150437

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