Interleukin 1 Receptor Antagonist (IL-1RA) Affinity Purified

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Test

A high affinity purification column was use to purify Interleukin 1 Receptor Antagonist (IL-1RA) by MyBioSource by chromatographic size exclusion.
Description

1 of protein A or G purified by MyBioSource will give more specificity than crude serum. The antagonist receptor ligand binding will be in contrast with agonist activity. MyBioSource produces more antagonist and receptor related products as 1. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

Gene target

Interleukin Receptor Antagonist IL-1RA
Gene symbol

IL1RN, IL6R, IL36G, IL25, IL22, IL18, IL37, IL1R1, IL17C, IL17A
Short name

Interleukin 1 Receptor Antagonist (IL-1RA)
Technique

affinity, purified, purifications
Alternative name

Interleukin 1 Receptor Antagonist (Interleukin-1RA) protein enriched
Alternative technique

pure

Identity

HGNC:6000
Gene

IL1RN
Long gene name

interleukin 1 receptor antagonist
Synonyms
- IL1RA
- ICIL-1RA
- IL1F3
- IRAP
- IL-1RN
- MGC10430
Synonyms name
- interleukin-1 receptor antagonist protein
- intracellular interleukin-1 receptor antagonist
GenBank acession
- M55646
Locus

2q14.1
Discovery year

1990-11-20
Entrez gene record

3557
Pubmed identfication
- 1386337
- 8432529
RefSeq identity
- NM_173841
Classification
- Interleukins
- Interleukin receptors
VEGA ID

OTTHUMG00000131341
Locus Specific Databases
- LRG_188

Identity

HGNC:6019
Gene

IL6R
Long gene name

interleukin 6 receptor
Synonyms
- CD126
- IL-6R
- IL-1Ra
- IL6RA
- gp80
Synonyms name
- membrane glycoprotein 80
- interleukin 6 receptor subunit alpha
GenBank acession
- X12830
Locus

1q21.3
Discovery year

2001-06-22
Entrez gene record

3570
Pubmed identfication
- 8428753
- 12633863
RefSeq identity
- NM_000565
Classification
- CD molecules
- Interleukin receptors
- Immunoglobulin like domain containing
VEGA ID

OTTHUMG00000036073

Identity

HGNC:5993
Gene

IL1R1
Long gene name

interleukin 1 receptor type 1
Synonyms gene
- IL1R
- IL1RA
Synonyms gene name
- interleukin 1 receptor, type I
Synonyms
- D2S1473
- CD121A
Synonyms name
- interleukin-1 receptor, type I
GenBank acession
- M27492
Locus

2q11.2-q12.1
Discovery year

1990-06-27
Entrez gene record

3554
Pubmed identfication
- 1833184
- 10191101
Classification
- I-set domain containing
- Interleukin receptors
- TIR domain containing
- CD molecules
VEGA ID

OTTHUMG00000130783

Identity

HGNC:5981
Gene

IL17A
Long gene name

interleukin 17A
Synonyms gene
- CTLA8
- IL17
Synonyms gene name
- interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
Synonyms
- IL-17A
- IL-17
Synonyms name
- cytotoxic T-lymphocyte-associated protein 8
GenBank acession
- U32659
Locus

6p12.2
Discovery year

1993-10-25
Entrez gene record

3605
Pubmed identfication
- 8390535
RefSeq identity
- NM_002190
Classification
- Interleukins
VEGA ID

OTTHUMG00000014840
Locus Specific Databases
- LRG_1223