CD130 (gp130 Receptor, Oncostatin M-R, OSM-R, IL-6 Signal Transducer)

• Catalog number
  MBS602318
• Price
  Please ask
• Size
  5x0.1 mg

• Products_type
  Antibody
• Products_short_name
  [CD130]
• Products_name_syn
  [Anti -CD130 (gp130 Receptor, Oncostatin M-R, OSM-R, IL-6 Signal Transducer)]
• Clonality
  Monoclonal
• Clone
  [3H1837]
• Reactivity
  Human
• Specificity
  Recognizes soluble and membrane bound human gp130 receptor. This antibody has been reported to block the activity of IL-6.
• Purity
  Highly Purified Purified by Ion Exchange chromatography.
• Form
  Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide, before the addition of glycerol to 40%.
• Storage_stability
  May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
• Tested_application
  ELISA (EL/EIA), Flow Cytometry (FC/FACS)
• Description
  The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

• Gene target
  CD130   gp130   Receptor   Oncostatin   M-R   OSM-R   IL-6   Signal   Transducer  
• Gene symbol
  MRAS, RRAS, DAD1P1, HNRNPR, CLDN4, MC1R, IL31RA, CTNNA2, PTPRK, MTNR1A
• Short name
  CD130 (gp130 Receptor, Oncostatin M-R, OSM-R, IL-6 Signal Transducer)
• Host
  Mouse
• Isotype
  IgG1
• Alternative name
  CD130 (gp130 Receptor, Oncostatin M-R, oncostatin M-R, Interleukin-6 Signal Transducer)
• Alternative to gene target
  oncostatin M, OSM and IDBG-4002 and ENSG00000099985 and 5008, growth factor activity, Extracellular, Osm and IDBG-142284 and ENSMUSG00000058755 and 18413, BT.45038 and IDBG-636338 and ENSBTAG00000016163 and 319086

Gene info

• Identity
  HGNC:7227
• Gene
  MRAS
• Long gene name
  muscle RAS oncogene homolog
• Synonyms
  • M-RAs
  • R-RAS3
  • RRAS3
• GenBank acession
  • AF022080
• Locus
  3q22.3
• Discovery year
  1999-09-29
• Entrez gene record
  22808
• Pubmed identfication
  • 9400994
  • 10446149
• Classification
  • RAS type GTPase family
• VEGA ID
  OTTHUMG00000159888

Gene info

• Identity
  HGNC:10447
• Gene
  RRAS
• Long gene name
  RAS related
• Synonyms gene name
  • related RAS viral (r-ras) oncogene homolog
• Synonyms
  • R-Ras
• Synonyms name
  • Oncogene RRAS
• Locus
  19q13.33
• Discovery year
  2001-06-22
• Entrez gene record
  6237
• Pubmed identfication
  • 3098437
• RefSeq identity
  • NM_006270
• Classification
  • RAS type GTPase family
• VEGA ID
  OTTHUMG00000183247

Gene info

• Identity
  HGNC:18295
• Gene
  DAD1P1
• Long gene name
  defender against cell death 1 pseudogene 1
• Synonyms gene
  • DAD1L
• Synonyms gene name
  • defender against cell death 1-like
• Synonyms
  • DAD-R
• Locus
  12p12.1
• Discovery year
  2007-07-26
• Entrez gene record
  56286
• Pubmed identfication
  • 10812081
  • 11912161
• RefSeq identity
  • NR_024064

Gene info

• Identity
  HGNC:5047
• Gene
  HNRNPR
• Long gene name
  heterogeneous nuclear ribonucleoprotein R
• Synonyms gene
  • HNRPR
• Synonyms
  • hnRNP-R
• GenBank acession
  • AF000364
• Locus
  1p36.12
• Discovery year
  1999-06-11
• Entrez gene record
  10236
• Pubmed identfication
  • 9421497
• RefSeq identity
  • NM_005826
• Classification
  • Heterogeneous nuclear ribonucleoproteins
  • RNA binding motif containing
• VEGA ID
  OTTHUMG00000003224

Gene info

• Identity
  HGNC:2046
• Gene
  CLDN4
• Long gene name
  claudin 4
• Synonyms gene
  • CPETR
  • CPETR1
• Synonyms
  • CPE-R
  • WBSCR8
  • hCPE-R
• Synonyms name
  • Clostridium perfringens enterotoxin receptor 1
  • Williams-Beuren syndrome chromosomal region 8 protein
• GenBank acession
  • AB000712
• Locus
  7q11.23
• Discovery year
  1998-04-22
• Entrez gene record
  1364
• Pubmed identfication
  • 9334247
  • 9892664
• RefSeq identity
  • NM_001305
• Classification
  • Claudins
• VEGA ID
  OTTHUMG00000023425

Gene info

• Identity
  HGNC:6929
• Gene
  MC1R
• Long gene name
  melanocortin 1 receptor
• Synonyms gene name
  • melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
• Synonyms
  • MSH-R
• Synonyms name
  • alpha melanocyte stimulating hormone receptor
• Locus
  16q24.3
• Discovery year
  1993-07-27
• Entrez gene record
  4157
• Pubmed identfication
  • 8458079
• RefSeq identity
  • NM_002386
• Classification
  • Melanocortin receptors
• VEGA ID
  OTTHUMG00000171163

Gene info

• Identity
  HGNC:18969
• Gene
  IL31RA
• Long gene name
  interleukin 31 receptor A
• Synonyms
  • CRL3
  • GLM-R
  • CRL
  • Glmr
  • IL-31RA
• GenBank acession
  • AY499339
• Locus
  5q11.2
• Discovery year
  2003-11-06
• Entrez gene record
  133396
• Pubmed identfication
  • 15184896
  • 11877449
• RefSeq identity
  • NM_139017
• Classification
  • Fibronectin type III domain containing
  • Interleukin receptors
• VEGA ID
  OTTHUMG00000097045

Gene info

• Identity
  HGNC:2510
• Gene
  CTNNA2
• Long gene name
  catenin alpha 2
• Synonyms gene name
  • catenin (cadherin-associated protein), alpha 2
• Synonyms
  • CAP-R
  • CT114
• Synonyms name
  • cadherin-associated protein, related
  • cancer/testis antigen 114
  • alpha-N-catenin
• Locus
  2p12
• Discovery year
  1993-07-13
• Entrez gene record
  1496
• Pubmed identfication
  • 8432524
• RefSeq identity
  • NM_004389
• Classification
  • Alpha catenins
• VEGA ID
  OTTHUMG00000152903

Gene info

• Identity
  HGNC:9674
• Gene
  PTPRK
• Long gene name
  protein tyrosine phosphatase receptor type K
• Synonyms
  • R-PTP-kappa
• GenBank acession
  • L77886
• Locus
  6q22.33
• Discovery year
  1998-02-09
• Entrez gene record
  5796
• Pubmed identfication
  • 9047348
  • 8663237
• Classification
  • Protein tyrosine phosphatases receptor type
  • Fibronectin type III domain containing
  • Immunoglobulin like domain containing
• VEGA ID
  OTTHUMG00000015536

Gene info

• Identity
  HGNC:7463
• Gene
  MTNR1A
• Long gene name
  melatonin receptor 1A
• Synonyms
  • MEL-1A-R
• Locus
  4q35.2
• Discovery year
  1995-03-22
• Entrez gene record
  4543
• Pubmed identfication
  • 7558006
• Classification
  • Melatonin receptors
• VEGA ID
  OTTHUMG00000185575

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