Recombinant Rat gp130 / IL6ST / CD130 Protein (His & Fc tag)

  • Catalog number
    PKSR030391-50µg
  • Price
    Please ask
  • Size
    50µg
  • Synonym
    Ac1055;Gp130;Il-6rb
  • Activity
    Measured by its ability to inhibit the IL6 Rα enhancement of IL6 activity on M1 mouse myeloid leukemia cells (Saito, T. et al. 1991, J. Immunol. 147:168.). The ED50 for this effect is typically 0.015-0.075 μg/ml in the presence of 50 ng/ml recombinant human IL6sR and 100 ng/ml recombinant human IL6.
  • Sequence
    Met 4-Glu 618
  • Fusion tag
    C-His & Fc
  • Accession
    NP_001008725.2
  • ExpressedHost
    HEK293 Cells
  • Shipping
    In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
  • Purity
    > 95 % as determined by SDS-PAGE
  • Endotoxin
    < 1.0 EU per μg of the protein as determined by the LAL method
  • Stability and Storage
    Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Mol Mass
    94.3 kDa
  • AP Mol Mass
    130 KDa
  • Formulation
    Lyophilized from sterile PBS, pH 7.4
  • Background
    Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. CD130/gp130 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.
  • Conjugation
    histidine
  • About
    Rats are used to make rat monoclonal anti mouse antibodies. There are less rat- than mouse clones however. Rats genes from rodents of the genus Rattus norvegicus are often studied in vivo as a model of human genes in Sprague-Dawley or Wistar rats.
  • Latin name
    Rattus norvegicus
  • Source
    Recombinants or rec. proteins
  • Group
    recombinants
  • Gene target
    gp130   IL6ST   CD130   Protein   His   tag  
  • Gene symbol
    IL6ST, IL6ST-DT
  • Short name
    Recombinant gp130 / IL6ST / CD130 Protein (His & Fc tag)
  • Technique
    Recombinant, FC, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
  • Host
    Rat
  • Label
    His
  • Species
    Rat, Rats
  • Alternative name
    Rec. Rat gp130 / interleukin 6 signal transducer (gp130, oncostatin M receptor) / CD130 Protein (histidine & fragment c detection labelled)
  • Alternative technique
    rec
  • Alternative to gene target
    interleukin 6 signal transducer (gp130, oncostatin M receptor), CD130 and CDW130 and GP130 and IL-6RB, IL6ST and IDBG-21516 and ENSG00000134352 and 3572, interleukin-27 receptor activity, Extracellular, Il6st and IDBG-182517 and ENSMUSG00000021756 and 16195, BT.66498 and IDBG-629050 and ENSBTAG00000017745 and 522155
Gene info
Gene info
  • Identity
  • Gene
  • Long gene name
    IL6ST divergent transcript
  • Locus
  • Discovery year
    2021-07-29
  • Entrez gene record
  • RefSeq identity
  • Classification
    • Divergent transcripts
MeSH Data
  • Name
  • Concept
    Scope note: The initial culturing of cells derived directly from fresh TISSUES.
  • Tree numbers
    • E01.370.225.500.223.500
    • E05.200.500.265.500
    • E05.242.223.500
    • E05.481.500.249.500
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
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