- Catalog numberPKSM040841-100µg
- Product nameRecombinant Mouse IL6ST / gp130 / CD130 Protein (His tag)
- Size100µg
- PriceAsk For Price
- Synonym5133400A03Rik;AA389424;BB405851;CD130;D13Ertd699e;gp130
- Activity1. Measured by its ability to bind mouse IL11Ra in a functional ELISA.2. Measured by its ability to inhibit the IL6 Rα enhancement of IL6 activity on M1 mouse myeloid leukemia cells (Saito, T. et al. 1991, J. Immunol. 147:168.). The ED50 for this effect is typically 0.6-3 μg/mL in the presence of 10 ng/mL recombinant human IL6 sR and 20 ng/mL recombinant human IL6.
- SequenceMet 1-Glu 617
- Fusion tagC-His
- AccessionNP_034690.3
- Expressed HostHEK293 Cells
- ShippingIn general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
- Purity> 97 % as determined by SDS-PAGE
- Endotoxin< 1.0 EU per μg of the protein as determined by the LAL method
- Stability and StorageSamples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
- Mol Mass68 kDa
- AP Mol Mass80-90 kDa
- FormulationLyophilized from sterile PBS, pH 7.4
- BackgroundGlycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. CD130/gp130 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events.
- Technical data
- Alternative to gene target
- [ "interleukin 6 signal transducer (gp130, oncostatin M receptor)", "CD130 and CDW130 and GP130 and IL-6RB", "IL6ST and IDBG-21516 and ENSG00000134352 and 3572", "interleukin-27 receptor activity", "Extracellular", "Il6st and IDBG-182517 and ENSMUSG00000021756 and 16195", "BT.66498 and IDBG-629050 and ENSBTAG00000017745 and 522155" ]
- Gene targetIL6ST / gp130 / CD130 Protein His tag
- Identity:HGNC:6021
- Gene:IL6ST
- Long gene name:interleukin 6 cytokine family signal transducer
- Synonyms gene name:interleukin 6 signal transducer (gp130, oncostatin M receptor), interleukin 6 signal transducer
- Synonyms:GP130, CD130sGP130IL-6RB
- Discovery year:1991-08-12
- Entrez gene record:3572
- Pubmed identification:2261637
- RefSeq identity:NM_002184
- Classification:Fibronectin type III domain containing, CD molecules, Interleukin receptors
- VEGA ID:OTTHUMG00000097043
- Identity:HGNC:55804
- Gene:IL6ST-DT
- Long gene name:IL6ST divergent transcript
- Discovery year:2021-07-29
- Entrez gene record:441072
- RefSeq identity:NR_102755
- Classification:Divergent transcripts
- Gene symbolIL6ST, IL6ST-DT
- Hostmouse
- Short nameRecombinant Mouse IL6ST / gp130 / CD130 Protein (His tag)
- LabelHis
- label filter
- His
- technique filter
- Recombinant
- Mouse
- TechniqueRecombinant, Mouse, mouses, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
- Alternative techniquerec, murine