ADAM 17, Propeptide Domain (A Disintegrin And Metalloproteinase 17, TNF-a Converting Enzyme, TACE, TNF alpha Converting Enzyme, CD156b)
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Catalog numberMBS611728
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Price:
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Size0.25 mL
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Products_typeAntibody
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Products_short_name[ADAM 17, Propeptide Domain]
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Products_name_syn[Anti -ADAM 17, Propeptide Domain (A Disintegrin And Metalloproteinase 17, TNF-a Converting Enzyme, TACE, TNF alpha Converting Enzyme, CD156b)]
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Other_names[ADAM metallopeptidase with thrombospondin type 1 motif, 17, isoform CRA_d; A disintegrin and metalloproteinase with thrombospondin motifs 17; A disintegrin and metalloproteinase with thrombospondin motifs 17; ADAM-TS17; ADAMTS-17; ADAM-TS 17; OTTHUMP00000194818; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 17; ADAM metallopeptidase with thrombospondin type 1 motif, 17]
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Other_gene_names[ADAMTS17; ADAMTS17; FLJ16363; FLJ32769]
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ClonalityPolyclonal
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ReactivityHuman, Mouse, Rat
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SpecificityRecognizes TACE. Species Crossreactivity: Human, Mouse and Rat.
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PurityAffinity Purified Purified by Protein A affinity chromatography.
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FormSupplied as a liquid in 10mM PBS, pH 7.4, 0.2% BSA and 0.09% sodium azide.
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Storage_stabilityMay be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Store at -20 degree C or colder. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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Tested_applicationELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP)
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DescriptionThe ADAM 17, Propeptide Domain (A Disintegrin Metalloproteinase 17, TNF-a Converting Enzyme, TACE, TNF alpha Converting Enzyme, CD156b) is a α- or alpha protein sometimes glycoprotein present in blood. Enzymes are cleaving the substrate. If the substrate is DNA they are called restriction enzymes. Activating enzymes will cut off the domain that is biological active to become functional.
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GeneTumor necrosis factor (TNFa, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. It is produced chiefly by activated macrophages, although it can be produced by many other cell types such as CD4+ lymphocytes, NK cells, neutrophils, mast cells, eosinophils, and neurons. TNFb or TNF beta also bin on TNF receptors for Th1 activation.
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Gene target
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Gene symbolTNF, TNFRSF1A, TNFRSF1B, LTBR, ADAMTS10, ADAMTS6, ADAM17, ADAMTS8, ADAMTS7, ADAMTS2
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Short nameADAM 17, Propeptide Domain (A Disintegrin Metalloproteinase 17, TNF-a Converting Enzyme, TACE, TNF alpha Converting Enzyme, CD156b)
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TechniqueEnzyme, enzymes
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HostRabbit
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Alternative nameADAM 17, Propeptide Domain (A Disintegrin And Metalloproteinase 17, tumor necrosis factor-a Converting Enzyme, TACE, tumor necrosis factor a Converting Enzyme, CD156b)
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Alternative techniqueenzymes
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Alternative to gene targettumor necrosis factor, DIF and TNF-alpha and TNFA and TNFSF2, TNF and IDBG-300259 and ENSG00000232810 and 7124, transcription regulatory region DNA binding, Extracellular, Tnf and IDBG-177358 and ENSMUSG00000024401 and 21926, TNF and IDBG-634161 and ENSBTAG00000025471 and 280943
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Gene info
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Identity
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Gene
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Long gene nametumor necrosis factor
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Synonyms gene
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Synonyms gene name
- tumor necrosis factor (TNF superfamily, member 2)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1986-01-01
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Entrez gene record
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Pubmed identfication
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Classification
- Tumor necrosis factor superfamily
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameTNF receptor superfamily member 1A
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Synonyms gene
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Synonyms gene name
- tumor necrosis factor receptor superfamily, member 1A
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Synonyms
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GenBank acession
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Locus
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Discovery year1991-01-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Tumor necrosis factor receptor superfamily
- CD molecules
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameTNF receptor superfamily member 1B
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Synonyms gene
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Synonyms gene name
- tumor necrosis factor receptor superfamily, member 1B
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Synonyms
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GenBank acession
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Locus
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Discovery year1991-01-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- CD molecules
- MicroRNA protein coding host genes
- Tumor necrosis factor receptor superfamily
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VEGA ID
Gene info
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Identity
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Gene
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Long gene namelymphotoxin beta receptor
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Synonyms gene
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1996-03-12
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Entrez gene record
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Pubmed identfication
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Classification
- Tumor necrosis factor receptor superfamily
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameADAM metallopeptidase with thrombospondin type 1 motif 10
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Synonyms gene name
- a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-04-05
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- ADAM metallopeptidases with thrombospondin type 1 motif
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameADAM metallopeptidase with thrombospondin type 1 motif 6
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Synonyms gene name
- a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 6
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1999-09-06
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- ADAM metallopeptidases with thrombospondin type 1 motif
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameADAM metallopeptidase domain 17
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Synonyms gene
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Synonyms gene name
- tumor necrosis factor, alpha, converting enzyme
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1997-04-10
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Entrez gene record
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Pubmed identfication
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Classification
- ADAM metallopeptidase domain containing
- CD molecules
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameADAM metallopeptidase with thrombospondin type 1 motif 8
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Synonyms gene name
- a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8
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Synonyms
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GenBank acession
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Locus
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Discovery year1999-08-23
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- ADAM metallopeptidases with thrombospondin type 1 motif
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameADAM metallopeptidase with thrombospondin type 1 motif 7
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Synonyms gene name
- a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 7
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1999-09-06
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- ADAM metallopeptidases with thrombospondin type 1 motif
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VEGA ID
Gene info
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Identity
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Gene
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Long gene nameADAM metallopeptidase with thrombospondin type 1 motif 2
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Synonyms gene name
- a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1999-04-15
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- ADAM metallopeptidases with thrombospondin type 1 motif
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VEGA ID