Recombinant Human IL-23 P19 Protein(His Tag) 10µg

• Catalog number
  PKSH030445-10µg
• Price
  Please ask
• Size
  10µg

• Synonym
  IL-23;IL-23A;IL23P19;P19;SGRF
• Activity
  Measured by its ability to bind biotinylated recombinant human IL12RB1 in a functional ELISA.Measured by its binding ability in a functional ELISA. Immobilized human IL23A-His+IL12B-His at 10 μg/ml (100 μl/well) can bind human IL23R-Fc. The EC50 of human IL23R-Fc is 0.28-0.66 μg/ml.Measured by its binding ability in a functional ELISA. Immobilized human IL23A-His+IL12B-His at 10 μg/ml (100 μl/well) can bind Cynomolgus IL23R-Fc. The EC50 of Cynomolgus IL23R-Fc is 0.14-0.35 μg/ml.Measured by its ability to induce IL17 secretion by mouse splenocytes. The ED50 for this effect is 4-20 ng/mL.
• Sequence
  Met 1-Pro 189
• Fusion tag
  C-His
• Accession
  Q9NPF7
• Expressed Host
  HEK293 Cells
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞90 % as determined by SDS-PAGE
• Endotoxin
  ＜1.0 EU per µg as determined by the LAL method
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  56.3 (20.1 + 36.2) kDa
• AP Mol Mass
  22 & 45 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.4
• Reconstitution
  Please refer to it for detailed information.
• Background
  Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The p19 subunit has homology to the p35 subunit of IL-12, as well as to other single chain cytokines such as IL-6 and IL-11. The p40 subunit is homologous to the extracellular domains of the hematopoietic cytokine receptors. Although p19 is expressed by activated macrophages, dendritic cells, T cells, and endothelial cells, only activated macrophages and dendritic cells express p40 concurrently to produce IL-23. IL-23 has biological activities that are similar to, but distinct from IL-12. Both IL-12 and IL-23 induce proliferation and IFN-gamma production by human T cells. While IL-12 acts on both naive and memory human T cells, the effects of IL-23 is restricted to memory T cells.
• Product URL
• PDF URL
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  IL-23   P19   Protein   His   Tag   10µg  
• Gene symbol
  IL23A, IL22, H3P13, IGHV3-23, IGKV2D-23, SNORD116-23, SNORD115-23, SNORD114-23, CDKN2D, IGKV2-23
• Short name
  Recombinant IL-23 P19 Protein(His Tag) 10µg
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens Interleukin-23 P19 Protein(histidine detection labelled) 10µg
• Alternative technique
  rec

Gene info

• Identity
  HGNC:15488
• Gene
  IL23A
• Long gene name
  interleukin 23 subunit alpha
• Synonyms gene name
  • interleukin 23, alpha subunit p19
• Synonyms
  • SGRF
  • IL23P19
  • IL-23
  • IL-23A
  • P19
• Synonyms name
  • interleukin-six, G-CSF related factor
• GenBank acession
  • AB030000
• Locus
  12q13.3
• Discovery year
  2001-04-10
• Entrez gene record
  51561
• Pubmed identfication
  • 11114383
• RefSeq identity
  • NM_016584
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000187402

Gene info

• Identity
  HGNC:14900
• Gene
  IL22
• Long gene name
  interleukin 22
• Synonyms
  • ILTIF
  • IL-21
  • zcyto18
  • IL-TIF
  • IL-D110
  • TIFa
  • TIFIL-23
  • IL-22
  • MGC79382
  • MGC79384
• Synonyms name
  • IL-10-related T-cell-derived inducible factor
• GenBank acession
  • AF279437
• Locus
  12q15
• Discovery year
  2001-03-12
• Entrez gene record
  50616
• Pubmed identfication
  • 10954742
  • 10875937
• RefSeq identity
  • NM_020525
• Classification
  • Interleukins
• VEGA ID
  OTTHUMG00000169119
• Locus Specific Databases
  • LRG_1248

Gene info

• Identity
  HGNC:43804
• Gene
  H3P13
• Long gene name
  H3 histone pseudogene 13
• Synonyms
  • p19
• Locus
  3q26.33
• Discovery year
  2019-08-02
• Entrez gene record
  115482685
• Pubmed identfication
  • 21782046
• RefSeq identity
  • NG_066038

Gene info

• Identity
  HGNC:5588
• Gene
  IGHV3-23
• Long gene name
  immunoglobulin heavy variable 3-23
• GenBank acession
  • M99660
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  28442
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152091

Gene info

• Identity
  HGNC:5796
• Gene
  IGKV2D-23
• Long gene name
  immunoglobulin kappa variable 2D-23 (pseudogene)
• Synonyms gene name
  • immunoglobulin kappa variable 2D-23
  • immunoglobulin kappa variable 2D-23 pseudogene
• GenBank acession
  • X71887
• Locus
  2p11.2
• Discovery year
  2000-04-18
• Entrez gene record
  28886
• RefSeq identity
  • NG_000833
• Classification
  • Immunoglobulin kappa locus at 2p11.2
• VEGA ID
  OTTHUMG00000151605

Gene info

• Identity
  HGNC:33089
• Gene
  SNORD116-23
• Long gene name
  small nucleolar RNA, C/D box 116-23
• Synonyms
  • HBII-85-23
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033434
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003337
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:33042
• Gene
  SNORD115-23
• Long gene name
  small nucleolar RNA, C/D box 115-23
• Synonyms
  • HBII-52-23
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-15
• Entrez gene record
  100033800
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003315.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:33011
• Gene
  SNORD114-23
• Long gene name
  small nucleolar RNA, C/D box 114-23
• Synonyms
  • 14q(II-23)
• Locus
  14q32.31
• Discovery year
  2006-09-26
• Entrez gene record
  767603
• Pubmed identfication
  • 12045206
• RefSeq identity
  • NR_003216.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:1790
• Gene
  CDKN2D
• Long gene name
  cyclin dependent kinase inhibitor 2D
• Synonyms gene name
  • cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
• Synonyms
  • INK4D
  • p19
• Locus
  19p13.2
• Discovery year
  1995-07-06
• Entrez gene record
  1032
• Pubmed identfication
  • 8575754
• RefSeq identity
  • NM_079421
• Classification
  • Ankyrin repeat domain containing
• VEGA ID
  OTTHUMG00000180583

Gene info

• Identity
  HGNC:5780
• Gene
  IGKV2-23
• Long gene name
  immunoglobulin kappa variable 2-23 (pseudogene)
• Synonyms gene name
  • immunoglobulin kappa variable 2-23
  • immunoglobulin kappa variable 2-23 pseudogene
• GenBank acession
  • X71885
• Locus
  2p11.2
• Discovery year
  2000-04-18
• Entrez gene record
  28924
• RefSeq identity
  • NG_000834
• Classification
  • Immunoglobulin kappa locus at 2p11.2
• VEGA ID
  OTTHUMG00000151638

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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