Recombinant Human DUSP14 / MKP-6 Protein (His & MBP tag) 100µg

• Catalog number
  PKSH030837-100µg
• Price
  Please ask
• Size
  100µg

• Synonym
  MKP-L;MKP6
• Activity
  NA
• Sequence
  Met 1 –His 191
• Fusion tag
  N-His & MBP
• Accession
  O95147
• Expressed Host
  E. coli
• Shipping
  In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
• Purity
  ＞88 % as determined by SDS-PAGE
• Endotoxin
  Please contact us for more information.
• Stability and Storage
  Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Mol Mass
  65 kDa
• AP Mol Mass
  60 kDa
• Formulation
  Lyophilized from sterile PBS, pH 7.5
• Reconstitution
  Please refer to it for detailed information.
• Background
  Dual specific phosphatase 14 / MAP-kinase phophatase-6 (DUSP14 / MKP6) is a member of Dual-specificity phosphatases that is a subclass of protein tyrosine phosphatases (PTP) families that can dephosphorylate bothe phosphotyrosine and phosphoserine / phosphothreonine residues in substrates. Unlike many other DUSPs, DUSP14 only contains a catalytic domain within the C-terminal region. In signal transduction, DUSP14 has been considered as negative regulator of the mitogen-activated protein kinase (MAPK) / extracellular signal-regulated kinase 1 / 2 (ERK 1 / 2) pathway. DUSP14 phosphatase activity has been confirmed to be inhibited by PTP inhibitor Ⅳ. PTP inhibitor binds to the catalytic site of DUSP14. PTP inhibitor Ⅳ effectively and specifically inhibited DUSP14-mediated dephosphorylation of JNK, a member of the mitogen-activated protein kinase (MAPK) family through dephosphorylation of both the Ser / Thr and Tyr residues of MAPKs. 
• Product URL
• PDF URL
• Conjugation
  histidine
• Properties
  Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
• Source
  Recombinants or rec. proteins
• Group
  recombinants

• Gene target
  DUSP14   MKP-6   Protein   His   MBP   tag   100µg  
• Gene symbol
  DUSP14, MBP, DUSP6, DUSP9, DUSP7, PRG2, DUSP10, DUSP16, DUSP1, ENO1
• Short name
  Recombinant DUSP14 / MKP-6 Protein (His & MBP tag) 100µg
• Technique
  Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
• Label
  His
• Species
  Human, Humans
• Alternative name
  Rec. H. sapiens DUSP14 / MKP-6 Protein (histidine & MBP detection labelled) 100µg
• Alternative technique
  rec

Gene info

• Identity
  HGNC:17007
• Gene
  DUSP14
• Long gene name
  dual specificity phosphatase 14
• Synonyms
  • MKP-L
  • MKP6
• Synonyms name
  • MKP-1 like protein tyrosine phosphatase
• GenBank acession
  • AF038844
• Locus
  17q12
• Discovery year
  2002-01-09
• Entrez gene record
  11072
• Pubmed identfication
  • 11123293
• RefSeq identity
  • NM_007026
• Classification
  • Atypical dual specificity phosphatases
• VEGA ID
  OTTHUMG00000188472

Gene info

• Identity
  HGNC:6925
• Gene
  MBP
• Long gene name
  myelin basic protein
• Locus
  18q23
• Discovery year
  1986-01-01
• Entrez gene record
  4155
• Pubmed identfication
  • 2425357
• RefSeq identity
  • NM_001025081
• VEGA ID
  OTTHUMG00000132874

Gene info

• Identity
  HGNC:3072
• Gene
  DUSP6
• Long gene name
  dual specificity phosphatase 6
• Synonyms
  • MKP-3
  • PYST1
• GenBank acession
  • BC037236
• Locus
  12q21.33
• Discovery year
  1997-03-19
• Entrez gene record
  1848
• Pubmed identfication
  • 8626780
  • 9205128
• RefSeq identity
  • NM_001946
  • NM_022652
• Classification
  • MAP kinase phosphatases
• VEGA ID
  OTTHUMG00000169912

Gene info

• Identity
  HGNC:3076
• Gene
  DUSP9
• Long gene name
  dual specificity phosphatase 9
• Synonyms
  • MKP-4
  • MKP4
• Synonyms name
  • map kinase phosphatase 4
• GenBank acession
  • Y08302
• Locus
  Xq28
• Discovery year
  1998-06-25
• Entrez gene record
  1852
• Pubmed identfication
  • 9030581
  • 9286695
• RefSeq identity
  • NM_001395
• Classification
  • MAP kinase phosphatases
• VEGA ID
  OTTHUMG00000024211

Gene info

• Identity
  HGNC:3073
• Gene
  DUSP7
• Long gene name
  dual specificity phosphatase 7
• Synonyms
  • MKP-X
  • PYST2
• GenBank acession
  • X93921
• Locus
  3p21.2
• Discovery year
  1997-03-19
• Entrez gene record
  1849
• Pubmed identfication
  • 8626780
  • 9205128
• RefSeq identity
  • NM_001947
• Classification
  • MAP kinase phosphatases
• VEGA ID
  OTTHUMG00000157819

Gene info

• Identity
  HGNC:9362
• Gene
  PRG2
• Long gene name
  proteoglycan 2, pro eosinophil major basic protein
• Synonyms gene name
  • proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
• Synonyms
  • MBP
  • BMPG
  • proMBP
• Synonyms name
  • eosinophil major basic protein
• GenBank acession
  • BC005929
• Locus
  11q12.1
• Discovery year
  1993-09-29
• Entrez gene record
  5553
• Pubmed identfication
  • 1565101
• RefSeq identity
  • NM_002728
• Classification
  • C-type lectin domain containing
• VEGA ID
  OTTHUMG00000167027

Gene info

• Identity
  HGNC:3065
• Gene
  DUSP10
• Long gene name
  dual specificity phosphatase 10
• Synonyms
  • MKP-5
  • MKP5
• GenBank acession
  • AB026436
• Locus
  1q41
• Discovery year
  1999-11-26
• Entrez gene record
  11221
• Pubmed identfication
  • 10391943
  • 10597297
• RefSeq identity
  • NM_007207
• Classification
  • MAP kinase phosphatases
• VEGA ID
  OTTHUMG00000037269

Gene info

• Identity
  HGNC:17909
• Gene
  DUSP16
• Long gene name
  dual specificity phosphatase 16
• Synonyms
  • MKP-7
  • KIAA1700
  • MKP7
• Synonyms name
  • MAPK phosphatase-7
• GenBank acession
  • AB052156
• Locus
  12p13.2
• Discovery year
  2002-08-20
• Entrez gene record
  80824
• Pubmed identfication
  • 11359773
  • 11489891
  • 15888437
• RefSeq identity
  • NM_030640
• Classification
  • MAP kinase phosphatases
• VEGA ID
  OTTHUMG00000168582

Gene info

• Identity
  HGNC:3064
• Gene
  DUSP1
• Long gene name
  dual specificity phosphatase 1
• Synonyms gene
  • PTPN10
• Synonyms
  • HVH1
  • CL100
  • MKP-1
• GenBank acession
  • X68277
• Locus
  5q35.1
• Discovery year
  1993-03-03
• Entrez gene record
  1843
• Pubmed identfication
  • 1406996
  • 7806236
• RefSeq identity
  • NM_004417
• Classification
  • MAP kinase phosphatases
• VEGA ID
  OTTHUMG00000130523

Gene info

• Identity
  HGNC:3350
• Gene
  ENO1
• Long gene name
  enolase 1
• Synonyms gene
  • ENO1L1
  • MPB1
• Synonyms gene name
  • enolase 1, (alpha)
• Synonyms
  • PPH
  • MBP-1
• Synonyms name
  • alpha-enolase
• GenBank acession
  • BC022545
• Locus
  1p36.23
• Discovery year
  1989-04-21
• Entrez gene record
  2023
• Pubmed identfication
  • 9653645
  • 9691177
• RefSeq identity
  • NM_001428
• Classification
  • Enolases
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000001773
• Locus Specific Databases
  • LRG_1165

MeSH Data

• Name
  Primary Cell Culture
• Concept
  Scope note: The initial culturing of cells derived directly from fresh TISSUES.
• Tree numbers
  • E01.370.225.500.223.500
  • E05.200.500.265.500
  • E05.242.223.500
  • E05.481.500.249.500
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

Product images

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