Recombinant Human CASK Kinase Protein (His & GST tag) 50µg
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Catalog number
PKSH030973-50µg
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Price
Please ask
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Size
50µg
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Synonym
CAGH39;CAMGUK;CMG;FGS4;LIN2;MICPCH;MRXSNA;TNRC8
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Activity
NA
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Sequence
Ala 2-Tyr 898
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Fusion tag
N-His & GST
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Accession
O14936-4
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Expressed Host
Baculovirus-Insect Cells
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Shipping
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.
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Purity
＞82 % as determined by SDS-PAGE
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Endotoxin
＜1.0 EU per µg as determined by the LAL method
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Stability and Storage
Samples are stable for up to twelve months from date of receipt at -70℃.Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Mol Mass
130 kDa
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AP Mol Mass
120 kDa
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Formulation
Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 7.4, 10% gly
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Reconstitution
Please refer to it for detailed information.
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Background
Peripheral plasma membrane protein CASK, also known as calcium/calmodulin-dependent serine protein kinase, CASK and LIN2, is a nucleus, cytoplasm and cell membrane protein which belongs to the MAGUK family. CASK / LIN2 contains one guanylate kinase-like domain, two L27 domains, one PDZ (DHR) domain, one protein kinase domain and one SH3 domain. CASK / LIN2 is ubiquitously expressed. Expression of CASK / LIN2 is significantly greater in brain relative to kidney, lung, and liver and in fetal brain and kidney relative to lung and liver. CASK / LIN2 is a multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. CASK / LIN2 contributes to neural development and regulation of gene expression via interaction with the transcription factor TRB1. It binds to cell-surface proteins, including amyloid precursor protein, neurexins and syndecans. CASK / LIN2 may mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Defects in CASK are the cause of mental retardation X-linked CASK-related (MRXCASK). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Defects in CASK are also the cause of FG syndrome type 4 which is an X-linked disorder characterized by mental retardation, relative macrocephaly, hypotonia and constipation.
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Conjugation
histidine
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Properties
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Source
Recombinants or rec. proteins
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Group
recombinants
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Gene target
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Gene symbol
CASK-AS1, MGST3, CASK
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Short name
Recombinant CASK Kinase Protein (His & GST tag) 50µg
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Technique
Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. Elabscience advises they will be reconstituted in a buffer soluion or culture medium for cell culture. Tags
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Label
His
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Species
Human, Humans
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Alternative name
Rec. H. sapiens calcium/calmodulin-dependent serine protein kinase (MAGUK family) phosphorylation catalyst Protein (histidine & GST detection labelled) 50µg
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Alternative technique
rec
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Alternative to gene target
calcium/calmodulin-dependent serine protein kinase (MAGUK family), CAGH39 and CAMGUK and CMG and FGS4 and LIN2 and MICPCH and MRXSNA and TNRC8, CASK and IDBG-57627 and ENSG00000147044 and 8573, transferase activity, nuclei, Cask and IDBG-133241 and ENSMUSG00000031012 and 12361, CASK and IDBG-637908 and ENSBTAG00000020136 and 404149
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Gene info
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Identity
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Gene
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Long gene name
CASK antisense RNA 1
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Synonyms gene name
- CASK antisense RNA 1 (non-protein coding)
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Locus
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Discovery year
2011-07-29
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Classification
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VEGA ID
Gene info
Gene info
MeSH Data
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Name
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Concept
Scope note:
Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
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Tree numbers
Product images
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