SIRT2 Inhibitor, AGK2

• Catalog number
  1651-10
• Price
  Please ask
• Size
  10 mg

• Alternative_name
  AGK2, (2E)-2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-(quinolin-5-yl)prop-2-enamide
• Description
  A potent inhibitor of sirtuin 2 (SIRT2) (IC₅₀ = 3.5 µM). AGK2 is >15-fold more selective for SIRT2 than SIRT1 and SIRt3. Inhibition of SIRT2 rescued α-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson’s disease.
• CAS Number
  304896-28-4
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₂₃H₁₃Cl₂N₃O₂
• Molecular Weight
  434.27
• Cell Permeable
  Yes
• Purity
  ≥95% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and light
• Tag Line
  A SIRT2 inhibitor
• Storage Condition
  +4°C
• Shipping Condition
  RT
• Shelf Life
  24 months
• MDL Number
  MFCD01909444
• PubChem CID
  2130404
• PubChem CID Link
• SMILES
  C1=CC2=C(C=CC=N2)C(=C1)NC(=O)C(=CC3=CC=C(O3)C4=C(C=CC(=C4)Cl)Cl)C#N
• InChi
  InChI=1S/C23H13Cl2N3O2/c24-15-6-8-19(25)18(12-15)22-9-7-16(30-22)11-14 (13-26)23(29)28-21-5-1-4-20-17(21)3-2-10-27-20/h1-12H,(H,28,29)/b14-11+
• InChi Key
  SVENPFFEMUOOGK-SDNWHVSQSA-N
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  SIRT2   Inhibitor   AGK2  
• Gene symbol
  SIRT2
• Short name
  SIRT2 Inhibitor, AGK2
• Alternative name
  SIRT2 suppressor, AGK2

Gene info

• Identity
  HGNC:10886
• Gene
  SIRT2
• Long gene name
  sirtuin 2
• Synonyms gene
  • SIR2L
• Synonyms gene name
  • sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2
  • sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)
• GenBank acession
  • AF083107
• Locus
  19q13.2
• Discovery year
  1998-10-14
• Entrez gene record
  22933
• Pubmed identfication
  • 10393250
  • 10381378
• Classification
  • Sirtuins
• VEGA ID
  OTTHUMG00000150480

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