SIRT2 Inhibitor
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Catalog number1857-25
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PricePlease ask
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Size25 mg
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Alternative_name3-(1-azepanylsulfonyl)-N-(3-bromphenyl)benzamide
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DescriptionBrain- permeable. A potent and selective sirtuin 2 deacetylase (SIRT2) inhibitor. Reduces neuronal cholesterol by inhibiting SIRT2 activity.
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CAS Number420831-40-9
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Structure AvailableYes
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Salt FormNo
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Molecular FormulaC₁₉H₂₁BrN₂O₃S
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Molecular Weight437.35
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Cell PermeableYes
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Purity≥98% by HPLC
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SolubilitiesDMSO
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HandlingProtect from air and light
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Tag LineA brain-permeable SIRT2 inhibitor
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Storage Condition-20°C
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Shipping Conditiongel pack
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Shelf Life24 months
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MDL NumberMFCD03140195
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PubChem CID1328033
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SMILESC1CCCN(CC1)S(=O)(=O)C2=CC=CC(=C2)C(=O)NC3=CC(=CC=C3)Br
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InChiInChI=1S/C19H21BrN2O3S/c20-16-8-6-9-17(14-16)21-19(23)15-7-5-10-18(13-15)26(24,25)22-11-3-1-2-4-12-22/h5-10,13-14H,1-4,11-12H2,(H,21,23)
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InChi KeyIYAYHZZWYNXHEQ-UHFFFAOYSA-N
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MSDS AvailableYes
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Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbolSIRT2
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Short nameSIRT2 Inhibitor
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Alternative nameSIRT2 suppressor
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Gene info
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Identity
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Gene
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Long gene namesirtuin 2
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Synonyms gene
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Synonyms gene name
- sirtuin (silent mating type information regulation 2, S.cerevisiae, homolog) 2
- sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)
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GenBank acession
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Locus
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Discovery year1998-10-14
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Entrez gene record
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Pubmed identfication
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Classification
- Sirtuins
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VEGA ID