PKM2 Inhibitor

• Catalog number
  B2593-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  MDK4882, PKM2 inhibitor(compound 3k), (3-methyl-1,4-dioxonaphthalen-2-yl)methyl piperidine-1-carbodithioate, compound 3k, PKM2 inhibitor, PKM2-IN-1
• Description
  PKM2 inhibitor is a potent pyruvate kinase M2 (PKM2) inhibitor (IC₅₀ = 2.95 μM).
• CAS Number
  94164-88-2
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₁₈H₁₉NO₂S₂
• Molecular Weight
  345.47
• Cell Permeable
  True
• Purity
  ≥98% by HPLC
• Solubilities
  in DMSO
• Handling
  Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
• Tag Line
  A pyruvate kinase M2 (PKM2) inhibitor
• Storage Condition
  -20ºC
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• PubChem CID
  131698387
• PubChem CID Link
• SMILES
  CC1=C(C(=O)C2=CC=CC=C2C1=O)CSC(=S)N3CCCCC3
• InChi
  InChI=1S/C18H19NO2S2/c1-12-15(11-23-18(22)19-9-5-2-6-10-19)17(21)14-8-4-3-7-13(14)16(12)20/h3-4,7-8H,2,5-6,9-11H2,1H3
• Data Sheet Link
• MSDS Available
  True
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  PKM2   Inhibitor  
• Gene symbol
  PKM
• Short name
  PKM2 Inhibitor
• Alternative name
  pyruvate kinase, muscle suppressor
• Alternative to gene target
  pyruvate kinase, muscle, CTHBP and HEL-S-30 and OIP3 and PK3 and PKM2 and TCB and THBP1, PKM2 and IDBG-20117 and ENSG00000067225 and 5315, poly(A) RNA binding, nuclei, Pkm and IDBG-173276 and ENSMUSG00000032294 and 18746, PKM2 and IDBG-645572 and ENSBTAG00000001601 and 512571

Gene info

• Identity
  HGNC:9021
• Gene
  PKM
• Long gene name
  pyruvate kinase M1/2
• Synonyms gene
  • PKM2
• Synonyms gene name
  • pyruvate kinase, muscle
• Synonyms
  • THBP1
  • OIP3
  • PK3
• GenBank acession
  • M23725
• Locus
  15q23
• Discovery year
  2001-06-22
• Entrez gene record
  5315
• Pubmed identfication
  • 2040271
• VEGA ID
  OTTHUMG00000172709

Similar products