HDAC8 Activity Fluorometric Assay Kit

• Catalog number
  K348-100
• Price
  Please ask
• Size
  100 assays

• Description
  Sensitive Assay, HTS
• Summary
  • Detection method- Fluorescence (Ex/Em = 380/500 nm) • Species reactivity- Mammalian • Applications- Suitable for high throughput measurement of HDAC8 activity in purified, immunoprecipitated and recombinant or genetically modified HDAC-8 samples.
• Sample Type
  Cell and tissue lysates, plasma and serum, other biological fluids
• Features Benefits
  • Simple procedure; takes ~ 60 min • Fast and convenient • Kit contains the necessary reagents for accurate measurement of HDAC-8 activity
• Storage Conditions
  -20°C
• Shipping Conditions
  gel pack
• Shelf life
  12 months
• Background
  Histone deacetylases (HDACs) represent a large family of enzymes identified as key regulators of nucleosomal histone acetylation, a major event that controls eukaryotic gene transcription and are classified into three groups. HDACs are transcriptional repressors with crucial roles in mammalian development. They are believed to be involved in important biological activities, such as cell differentiation, proliferation, apoptosis, and senescence. In BioVision’s HDAC-8 activity Kit, HDAC-8 deacetylates the substrate (R-H-K(Ac)-K(Ac)-AFC) followed by an enzymatic cleavage to release the quenched fluorescent group (AFC), which can be detected at Em/Ex = 380/500 nm. The kit provides a rapid, simple, sensitive, and reliable test, which is also suitable for high throughput measurement of HDAC-8 activity in purified, immunoprecipitated and recombinant or genetically modified HDAC-8 samples.
• Data Sheet Link
• Test
  Biovision supplies other types of Assays as 1.

• Gene target
  HDAC8   Activity   Fluorometric   Kit  
• Gene symbol
  HDAC8
• Short name
  HDAC8 Activity Fluorometric Assay Kit
• Technique
  Assay, assays
• Host
  Assay
• Alternative name
  HDAC8 Activity fluorescence test reagent
• Alternative technique
  arrays, kits
• Alternative to gene target
  v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, C-Kit and CD117 and PBT and SCFR, KIT and IDBG-18980 and ENSG00000157404 and 3815, transferase activity, Extracellular, Kit and IDBG-172083 and ENSMUSG00000005672 and 16590, KIT and IDBG-642326 and ENSBTAG00000002699 and 280832

Gene info

• Identity
  HGNC:13315
• Gene
  HDAC8
• Long gene name
  histone deacetylase 8
• Synonyms gene
  • HDACL1
  • WTS
  • MRXS6
• Synonyms gene name
  • histone deacetylase-like 1
  • Wilson-Turner X-linked mental retardation syndrome
• Synonyms
  • RPD3
  • KDAC8
• GenBank acession
  • AF230097
• Locus
  Xq13.1
• Discovery year
  2000-11-28
• Entrez gene record
  55869
• Pubmed identfication
  • 10756090
  • 10922473
  • 22889856
• RefSeq identity
  • NM_018486
• Classification
  • Histone deacetylases, class I
• VEGA ID
  OTTHUMG00000021814
• Locus Specific Databases
  • Global Variome shared LOVD

Product images

Similar products