Cathepsin S Inhibitor Screening Kit (Fluorometric)

• Catalog number
  K149-100
• Price
  617.35 USD
• Size
  100 assays

• Description
  Only kit on the market to screen Cathepsin S inhibitors
• Summary
  • Detection method- Fluorescence (Ex/Em = 400/505 nm) • Applications- Screen/study/characterize potential inhibitors of Cathepsin S.
• Detection Method
  Fluorescence (Ex/Em = 400/505 nm)
• Applications
  Screen/study/characterize potential inhibitors of Cathepsin S.
• Features Benefits
  • Simple & convenient • High-throughput adaptable assay to screen/study/characterize the potential inhibitors of Cathepsin S • Cathepsin S inhibitor, Z-FF-FMK is included in the kit
• Storage Conditions
  -20°C
• Shipping Conditions
  gel pack
• Shelf life
  12 months
• Background
  Cathepsin S (CTSS, EC 3.4.22.27) is a lysosomal cysteine proteinase that is suggested to participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. Biovision’s Cathepsin S Inhibitor Screening Kit utilizes the ability of Cathepsin S to cleave the synthetic AFC based peptide substrate to release AFC, which can be easily quantified using a fluorometer or fluorescence microplate reader. In the presence of a Cathepsin S inhibitor, the cleavage of the substrate is reduced/abolished resulting in decrease or total loss of the AFC fluorescence. This high-throughput adaptable assay kit is simple, sensitive, and rapid tool to screen the potential inhibitors of Cathepsin S.
• Data Sheet Link
• Gene
  CTS protease activity also measured by zymograph electrophoresis of Cathepsins. This cathepsin is supplied in 1.
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  Cathepsin   Inhibitor   Screening   Kit   Fluorometric  
• Short name
  Cathepsin S Inhibitor Screening Kit (Fluorometric)
• Alternative name
  Cathepsin S suppressor detection reagent (fluorescence)
• Alternative technique
  kits
• Alternative to gene target
  v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, C-Kit and CD117 and PBT and SCFR, KIT and IDBG-18980 and ENSG00000157404 and 3815, transferase activity, Extracellular, Kit and IDBG-172083 and ENSMUSG00000005672 and 16590, KIT and IDBG-642326 and ENSBTAG00000002699 and 280832

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