Apolipoprotein AIV, Human Plasma

  • Catalog number
    7282-50
  • Price
    Please ask
  • Size
    50 ug
  • Synonyms
    Apolipoprotein A-IV, apo AIV, Apo-AIV, ApoA-IV
  • Alternative_names
    Apolipoprotein A-IV, apo AIV, Apo-AIV, ApoA-IV
  • Description
    Apo AIV alters the activity of the key enzymes (LPL and LCAT) of lipoprotein metabolism and cholesterol efflux
  • Recombinant
    No
  • Source
    Human plasma. Prepared from plasma shown to be non-reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
  • Purity by SDS PAGE
    ≥85%
  • Assay
    SDS-PAGE
  • Molecular Weight
    46 kDa
  • Storage Temp
    -80°C
  • Shipping
    Dry Ice
  • Shelf Life
    12 months
  • Appearance
    Frozen
  • Physical form description
    Frozen in 10 mM NH4HCO3, pH 8.2
  • Background Information
    Apolipoprotein AIV (Apo AIV) is a glycoprotein synthesized by the human intestine. Synthesis appears to be stimulated by the absorption of high density lipoproteins that are rich in triglycerides rather than by the uptake or re-esterification of fatty acids. The formation of chylomicrons acts as a signal for the induction of Apo AIV synthesis a signal enhanced by a factor from the ileum, probably PYY. Apo AIV alters the activity of the key enzymes (LPL and LCAT) of lipoprotein metabolism and cholesterol efflux from extra hepatic tissues. Also, since stimulation of intestinal synthesis and secretion by lipid absorption are rapid, Apo AIV likely plays a role in the short-term regulation of food intake. Other evidence suggests involvement in the long-term regulation of both food intake and body weight. Chronic ingestion of high-fat diet blunts the intestinal Apo AIV response to lipid feeding and, consequently, may explain why the chronic ingestion of a high-fat diet predisposes both animals and humans to obesity. It is required for efficient activation of lipoprotein lipase by ApoC-II and is a potent activator of LCAT. Apo AIV is an amphipathic protein that can emulsify lipids and has been linked to protective roles against cardiovascular disease and obesity.
  • Handling
    Centrifuge the vial prior to opening.
  • Usage
    For Research Use Only! Not to be used in humans
  • Properties
    Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • Gene target
  • Short name
    Apolipoprotein AIV, Plasma
  • Species
    Human, Humans
  • Alternative name
    Apolipoprotein AIV, H. sapiens Plasma
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