ACE-2 Substrate, Fluorogenic

• Catalog number
  B2726-5
• Price
  Please ask
• Size
  5 mg

• Alternative_name
  Mca-Ala-Pro-Lys(Dnp)-OH [Mca=(7-methoxycoumarin-4-yl)acetyl;Dnp=2,4-dinitrophenyl],Mca-APK(Dnp),ACE2 Substrate
• Description
  ACE-2 substrate, Fluorogenic is a useful fluorogenic substrate for angiotensin converting enzyme-2 (ACE-2), a zinc-dependent carboxypeptidase with 42% amino acid sequence identity to ACE1. Unlike Mca-YVADAPK(Dnp)-OH (Cat. No. B2717), this substrate is not cleaved by caspases. This peptide substrate contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. This substrate is useful for inhibitor screening and kinetic analysis. Ex: 328 nm, Em: 393 nm.
• Structure Available
  No
• Peptide sequence
  Mca-Ala-Pro-Lys(Dnp)-OH
• Salt Form
  No
• Molecular Formula
  C₃₂H₃₇N₆O₁₂
• Molecular Weight
  697.7
• Cell Permeable
  1
• Purity
  ≥95% by HPLC
• Solubilities
  ~2 mg/ml DMSO
• Handling
  Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
• Tag Line
  A fluorogenic ACE-2 (Angiotensin I-converting enzyme 2) substrate
• Storage Condition
  -20ºC
• Shipping Condition
  Gel Pack
• Shelf Life
  36 months
• Data Sheet Link
• MSDS Available
  1

• Gene target
  ACE-2   Substrate   Fluorogenic  
• Gene symbol
  ACE2, ACE, MIR7-2, MIR329-2, MIR512-2, MIR521-2, MIR1289-2, MIR509-2, KRTAP13-2, RNU6-2
• Short name
  ACE-2 Substrate, Fluorogenic
• Alternative name
  Angiotensin-converting enzyme; Uncharacterized protein-2 Substrate, Fluorogenic
• Alternative to gene target
  Angiotensin-converting enzyme; Uncharacterized protein, ACE and IDBG-728302 and ENSG00000264813 and, peptidyl-dipeptidase activity, Plasma membranes

Gene info

• Identity
  HGNC:13557
• Gene
  ACE2
• Long gene name
  angiotensin converting enzyme 2
• Synonyms gene name
  • angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
  • angiotensin I converting enzyme 2
• Synonyms
  • ACEH
• Synonyms name
  • peptidyl-dipeptidase A
• GenBank acession
  • AF291820
• Locus
  Xp22.2
• Discovery year
  2000-09-25
• Entrez gene record
  59272
• Pubmed identfication
  • 10969042
• VEGA ID
  OTTHUMG00000021177
• Locus Specific Databases
  • Global Variome shared LOVD

Gene info

• Identity
  HGNC:2707
• Gene
  ACE
• Long gene name
  angiotensin I converting enzyme
• Synonyms gene
  • DCP1
• Synonyms gene name
  • angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
• Synonyms
  • ACE1
  • CD143
• Synonyms name
  • peptidyl-dipeptidase A
• GenBank acession
  • J04144
• Locus
  17q23.3
• Discovery year
  1989-06-06
• Entrez gene record
  1636
• Pubmed identfication
  • 2554286
  • 10319862
• RefSeq identity
  • NM_000789
• Classification
  • CD molecules
• VEGA ID
  OTTHUMG00000154927

Gene info

• Identity
  HGNC:31639
• Gene
  MIR7-2
• Long gene name
  microRNA 7-2
• Synonyms gene
  • MIRN7-2
• Synonyms
  • hsa-mir-7-2
• Locus
  15q26.1
• Discovery year
  2004-04-23
• Entrez gene record
  407044
• RefSeq identity
  • NR_029606
• Classification
  • MicroRNA MIR7 family

Gene info

• Identity
  HGNC:32051
• Gene
  MIR329-2
• Long gene name
  microRNA 329-2
• Synonyms gene
  • MIRN329-2
• Synonyms
  • hsa-mir-329-2
• Locus
  14q32.31
• Discovery year
  2005-07-11
• Entrez gene record
  574409
• RefSeq identity
  • NR_029968
• Classification
  • MicroRNA MIR329 family

Gene info

• Identity
  HGNC:32091
• Gene
  MIR512-2
• Long gene name
  microRNA 512-2
• Synonyms gene
  • MIRN512-2
• Synonyms
  • hsa-mir-512-2
• Locus
  19q13.42
• Discovery year
  2005-07-15
• Entrez gene record
  574459
• RefSeq identity
  • NR_030181
• Classification
  • MicroRNA MIR506 family

Gene info

• Identity
  HGNC:32113
• Gene
  MIR521-2
• Long gene name
  microRNA 521-2
• Synonyms gene
  • MIRN521-2
• Synonyms
  • hsa-mir-521-2
• Locus
  19q13.42
• Discovery year
  2005-07-15
• Entrez gene record
  574481
• RefSeq identity
  • NR_030203
• Classification
  • MicroRNA MIR515 family

Gene info

• Identity
  HGNC:35282
• Gene
  MIR1289-2
• Long gene name
  microRNA 1289-2
• Synonyms gene
  • MIRN1289-2
• Synonyms
  • hsa-mir-1289-2
• Locus
  5q31.1
• Discovery year
  2008-11-03
• Entrez gene record
  100302134
• RefSeq identity
  • NR_031621
• Classification
  • MicroRNA MIR1289 family

Gene info

• Identity
  HGNC:33641
• Gene
  MIR509-2
• Long gene name
  microRNA 509-2
• Synonyms gene
  • MIRN509-2
• Synonyms
  • hsa-mir-509-2
• Locus
  Xq27.3
• Discovery year
  2007-10-24
• Entrez gene record
  100126301
• RefSeq identity
  • NR_030586
• Classification
  • MicroRNA MIR506 family

Gene info

• Identity
  HGNC:18923
• Gene
  KRTAP13-2
• Long gene name
  keratin associated protein 13-2
• Synonyms
  • KAP13-2
• GenBank acession
  • AP001708
• Locus
  21q22.11
• Discovery year
  2003-02-21
• Entrez gene record
  337959
• Pubmed identfication
  • 12359730
• Classification
  • Keratin associated proteins
• VEGA ID
  OTTHUMG00000057793

Gene info

• Identity
  HGNC:34270
• Gene
  RNU6-2
• Long gene name
  RNA, U6 small nuclear 2
• Synonyms
  • U6-2
• Locus
  19p13.3
• Discovery year
  2008-06-10
• Entrez gene record
  103625684
• Pubmed identfication
  • 12711679
• RefSeq identity
  • NR_125730
• Classification
  • Small nuclear RNAs

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