PSAP Antibody

• Catalog number
  bs-1879R
• Price
  Please ask
• Size
  0.1ml

• Long name
  PSAP Primary Polyclonal Antibody
• Also known as
  PSAP PAb
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  PSAP/PAP
• Specificity
  This is a highly specific antibody against PSAP/PAP.
• Modification s
  None
• Modification site s
  Unmodified antibody
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen range
  144-194/524
• Subcellular location
  Secreted
• Source
  This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PSAP
• Gene ID number
  5660
• Swiss Prot
  P07602
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12). Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  GLBA; SAP1; Prosaposin; Proactivator polypeptide; PSAP
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  PSAP  
• Gene symbol
  PSAP, MTCH1
• Short name
  Anti-PSAP/PAP
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  PSAP Polyclonal Antibody
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:9498
• Gene
  PSAP
• Long gene name
  prosaposin
• Synonyms gene
  • SAP1
  • GLBA
  • SAP2
• Synonyms gene name
  • sphingolipid activator protein-1
  • sphingolipid activator protein-2
• Synonyms name
  • variant Gaucher disease and variant metachromatic leukodystrophy
  • saposin-A
  • saposin-B
  • saposin-C
  • saposin-D
• GenBank acession
  • BC004275
• Locus
  10q22.1
• Discovery year
  1986-01-01
• Entrez gene record
  5660
• Pubmed identfication
  • 2717620
• RefSeq identity
  • NM_002778
• Classification
  • Receptor ligands
• VEGA ID
  OTTHUMG00000018429

Gene info

• Identity
  HGNC:17586
• Gene
  MTCH1
• Long gene name
  mitochondrial carrier 1
• Synonyms gene name
  • mitochondrial carrier homolog 1 (C. elegans)
• Synonyms
  • CGI-64
  • PSAP
  • SLC25A49
• Synonyms name
  • solute carrier family 25, member 49
• GenBank acession
  • AF151822
• Locus
  6p21.2
• Discovery year
  2003-05-20
• Entrez gene record
  23787
• Pubmed identfication
  • 12377771
• RefSeq identity
  • NM_014341
• Classification
  • Solute carriers
• VEGA ID
  OTTHUMG00000014614

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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