HDAC4 (Ser632) / HDAC5 (Ser498) / HDAC7 (Ser486) Antibody

• Catalog number
  bs-3211R
• Price
  Please ask
• Size
  0.1ml

• Long name
  HDAC4 (Ser632) / HDAC5 (Ser498) / HDAC7 (Ser486) Antibody
• Also known as
  HDAC4 (Ser632) / HDAC5 (Ser498) / HDAC7 (Ser486) Antibody
• Category
  Primary Antibodies
• Conjugation
  Unconjugated
• Target Antigen
  HDAC4 Ser632 / HDAC5 Ser498 / HDAC7 Ser486
• Specificity
  This is a highly specific antibody against HDAC4 Ser632 / HDAC5 Ser498 / HDAC7 Ser486.
• Modification s
  Phosphorylation
• Modification site s
  Ser632/Ser498/Ser486
• Clonality
  Polyclonal antibody
• Clone number
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic phosphopeptide derived from human HDAC4 around the phosphorylation site of Ser632
• Gene ID number
  9759
• Tested Applications
  WB, IHC-P, IF(IHC-P)
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
• Cross reactivity
  Human, Mouse, Rat
• Cross reactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Background of the target antigen
  HDAC4 is a class II histone deacetylase containing 1084 amino acid residues. HDAC4 has been shown to interact with NCoR. HDAC4 is a member of the class II mammalian histone deacetylases, which consists of 1084 amino acid residues. Its C terminal sequence is highly similar to the deacetylase domain of yeast HDA1. HDAC4, unlike other deacetylases, shuttles between the nucleus and cytoplasm in a process involving active nuclear export. Association of HDAC4 with 14-3-3 results in sequestration of HDAC 4 protein in the cytoplasm. In the nucleus, HDAC4 associates with the myocyte enhancer factor MEF2A. Binding of HDAC4 to MEF2A results in the repression of MEF2A transcriptional activation. HDAC4 has also been shown to interact with other deacetylases such as HDAC3 as well as the corepressors NcoR and SMART.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for up to 1 year.
• Synonym names
  HDAC5 Ser498; HDAC4 Ser632; HDAC7 Ser486; HD 4; HD4; HDAC 4; HDAC A; HDACA; Histone Deacetylase 4; Histone Deacetylase A; KIAA0288; EC 3.5.1.98; HA6116; HD 5; HD5; HDAC 5; Histone deacetylase 5; KIAA0600; NY CO 9; Antigen NY CO 9; FLJ90614; HDAC4_HUMAN; HDAC5_HUMAN; HDAC7_HUMAN.
• Properties
  If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.
• French translation
  anticorps

• Gene target
  HDAC4   Ser632   HDAC5   Ser498   HDAC7   Ser486  
• Gene symbol
  HDAC4-AS1, HDAC7, HDAC5, HDAC4
• Short name
  Anti-HDAC4 Ser632 / HDAC5 Ser498 / HDAC7 Ser486
• Technique
  Antibody, antibodies against human proteins, antibodies for
• Host
  Rabbit (Oryctolagus cuniculus)
• Isotype
  Immunoglobulin G (IgG)
• Alternative name
  HDAC4 (Ser632) / HDAC5 (Ser498) / HDAC7 (Ser486) Antibody
• Alternative technique
  antibodies
• Alternative to gene target
  histone deacetylase 7, HDAC7 and IDBG-29060 and ENSG00000061273 and 51564, NAD-dependent histone deacetylase activity (H3-K18 specific), nuclei, Hdac7 and IDBG-179042 and ENSMUSG00000022475 and 56233, HDAC7 and IDBG-633011 and ENSBTAG00000026819 and 509843

Gene info

• Identity
  HGNC:54064
• Gene
  HDAC4-AS1
• Long gene name
  HDAC4 antisense RNA 1
• Locus
  2q37.3
• Discovery year
  2018-09-27
• Entrez gene record
  101928111
• RefSeq identity
  • NR_135575
• Classification
  • Antisense RNAs

Gene info

• Identity
  HGNC:14067
• Gene
  HDAC7
• Long gene name
  histone deacetylase 7
• Synonyms gene
  • HDAC7A
• Synonyms gene name
  • histone deacetylase 7A
• Synonyms
  • DKFZP586J0917
• GenBank acession
  • AF239243
• Locus
  12q13.11
• Discovery year
  2001-07-13
• Entrez gene record
  51564
• Pubmed identfication
  • 10922406
  • 10640276
• Classification
  • Histone deacetylases, class IIA
• VEGA ID
  OTTHUMG00000152968

Gene info

• Identity
  HGNC:14068
• Gene
  HDAC5
• Long gene name
  histone deacetylase 5
• Synonyms
  • KIAA0600
  • NY-CO-9
  • FLJ90614
• GenBank acession
  • AF249731
• Locus
  17q21.31
• Discovery year
  2000-11-28
• Entrez gene record
  10014
• Pubmed identfication
  • 10220385
  • 9610721
• RefSeq identity
  • NM_001015053
• Classification
  • Histone deacetylases, class IIA
• VEGA ID
  OTTHUMG00000181806

Gene info

• Identity
  HGNC:14063
• Gene
  HDAC4
• Long gene name
  histone deacetylase 4
• Synonyms gene
  • BDMR
• Synonyms gene name
  • brachydactyly-mental retardation syndrome
• Synonyms
  • KIAA0288
  • HDAC-A
  • HDACA
  • HD4
  • HA6116
  • HDAC-4
• GenBank acession
  • AB006626
• Locus
  2q37.3
• Discovery year
  2000-11-28
• Entrez gene record
  9759
• Pubmed identfication
  • 10206986
  • 10220385
  • 20691407
• RefSeq identity
  • NM_006037
• Classification
  • Histone deacetylases, class IIA
  • MicroRNA protein coding host genes
• VEGA ID
  OTTHUMG00000133344

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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