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anti-HDAC4 / HDAC5 / HDAC9 (phospho Ser246 / Ser259 / Ser220) Antibody

  • Catalog number
    79-244
  • Product name
    anti-HDAC4 / HDAC5 / HDAC9 (phospho Ser246 / Ser259 / Ser220) Antibody
  • Size
    0.1 mg
  • Gene info
    Histone Deacetylases (HDACs) are a group of enzymes closely related to sirtuins. They catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, resulting in transcriptional repression. In general, they do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways. There are three classes of HDACs; classes 1, 2 and 4, which are closely related Zn2+-dependent enzymes. HDACs are ubiquitously expressed and they can exist in the nucleus or cytosol. Their subcellular localization is effected by protein-protein interactions (for example HDAC-14.3.3 complexes are retained in the cytosol) and by the class to which they belong (class 1 HDACs are predominantly nuclear whilst class 2 HDACs shuttle between the nucleus and cytosol). HDACs have a role in cell growth arrest, differentiation and death and this has led to substantial interest in HDAC inhibitors as possible antineoplastic agents.
  • Gene names
    HD4, AHO3, BDMR, HDACA, HA6116, HDAC-4, HDAC-A, CYK18, PIG46, HD4/HD5/HD9,
  • Antibodie s label
    unlabelled serum
  • Purity
    Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
  • Ab raised in
    Rabbit
  • Type
    Polyclonal
  • Spicific to
    This antibody detects endogenous level of HDAC4/HDAC5/HDAC9 only when phosphorylated at serine 246/259/220.
  • Antigen
    HDAC4/HDAC5/HDAC9 (phospho-Ser246/259/220) antibody was made against a peptide sequence around phosphorylation site of serine 246/259/220 (T-A-S (p) -EP) derived from Human HDAC4/HDAC5/HDAC9.
  • Immuno application
    Western Blot, immuno-histo-chemistry
  • Antibody advice
    Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100
  • Suspention pH azide
    Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Keep at
    Store antibody at -20 grades C for up to one year.
  • Works with
    Human
  • Omim nr
    153085395 / 62750349 / 7662280
  • Ncbi nr
    NP_006028.2 / NP_001015053.1 / NP_055522.1
  • KDa
    140, 124 kDa
  • Vial with antibody
    in solution
  • Quantity per ml
    1 mg/mL
  • NCBI GENE nr
    9759 / 10014 / 9734
  • GENE symbol
    HDAC4 HDAC5 HDAC9
  • Antigene name
    histone deacetylase 4 / histone deacetylase 5 / histone deacetylase 9
  • Source
    Homo sapiens
  • Protein nr
    P56524 Q9UQL6 Q9UKV0
  • Picture
    Picture
  • Pdf tech file
    Pdf_tech_file
  • More antibodies
    More_antibodies
  • Alternative to gene target
    • [ "histone deacetylase 9", "HD7 and HD7b and HD9 and HDAC and HDAC7 and HDAC7B and HDAC9B and HDAC9FL and HDRP and MITR", "HDAC9 and IDBG-9049 and ENSG00000048052 and 9734", "NAD-dependent histone deacetylase activity (H3-K18 specific)", "nuclei", "Hdac9 and IDBG-134566 and ENSMUSG00000004698 and 79221", "HDAC9 and IDBG-629964 and ENSBTAG00000003808 and 535415" ]
    • [ "histone deacetylase 5", "HD5 and NY-CO-9", "HDAC5 and IDBG-53295 and ENSG00000108840 and 10014", "NAD-dependent histone deacetylase activity (H3-K18 specific)", "nuclei", "Hdac5 and IDBG-212520 and ENSMUSG00000008855 and 15184", "HDAC5 and IDBG-640847 and ENSBTAG00000016254 and 504242" ]
    • [ "histone deacetylase 4", "AHO3 and BDMR and HA6116 and HD4 and HDAC-4 and HDAC-A and HDACA", "HDAC4 and IDBG-84594 and ENSG00000068024 and 9759", "NAD-dependent histone deacetylase activity (H3-K18 specific)", "nuclei", "Hdac4 and IDBG-181579 and ENSMUSG00000026313 and 208727", "HDAC4 and IDBG-642244 and ENSBTAG00000017764 and 517559" ]
  • Gene target
    HDAC4 / HDAC5 / HDAC9 phospho Ser246 / Ser259 / Ser220
    • Gene info
    • Identity:HGNC:40664
    • Gene:HDAC9-AS1
    • Long gene name:HDAC9 antisense RNA 1
    • Discovery year:2019-08-07
    • Entrez gene record:105375176
    • Classification:Antisense RNAs
    Gene info
    Gene info
    Gene info
    Gene info
  • Gene symbol
    HDAC9-AS1, HDAC4-AS1, HDAC9, HDAC5, HDAC4
  • Short name
    anti-HDAC4 / HDAC5 / HDAC9 (phospho Ser246 / Ser259 / Ser220) Antibody
  • technique filter
    • Antibody
    • anti-
    • anti
  • Technique
    Antibody, anti-, anti, antibody to, antibodies, antibodies against human proteins, antibodies for
  • Alternative technique
    antibodies