RUNX1 (Ser266) Antibody, HRP Conjugated

• Catalog number
  bs-3024R-HRP
• Price
  Please ask
• Size
  0.1ml

• Long name
  RUNX1 (Ser266) Polyclonal Antibody, HRP Conjugated
• Category
  Conjugated Primary Antibodies
• Conjugation
  HRP
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  RUNX1 Ser266
• Specificity
  This is a highly specific antibody against RUNX1 Ser266.
• Modification
  Phosphorylation
• Modification site
  Ser266
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Immunogen_range
  240-280/453
• Subcellular location
  Nucleus
• Source
  KLH conjugated synthetic phosphopeptide derived from human RUNX1 around the phosphorylation site of Ser266
• Gene ID number
  861
• Swiss Prot
  Q01196
• Tested applications
  WB, IHC-P
• Recommended dilutions
  WB(1:100-1000), IHC-P(1:100-500)
• Crossreactivity
  Human
• Crossreactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Antigen background
  CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B-dependent transcriptional activation. Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (PubMed:17377532).
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% Gentamicin. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
• Excitation Emission
  N/A
• Synonyms
  AML1; CBFA2; EVI-1; AMLCR1; PEBP2aB; CBF2alpha; AML1-EVI-1; PEBP2alpha; Runt-related transcription factor 1; Acute myeloid leukemia 1 protein; Core-binding factor subunit alpha-2; CBF-alpha-2; Oncogene AML-1; Polyomavirus enhancer-binding protein 2 alpha B subunit; PEA2-alpha B; PEBP2-alpha B; SL3-3 enhancer factor 1 alpha B subunit; SL3/AKV core-binding factor alpha B subunit; RUNX1
• Properties
  If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. HRP conjugates are often primary rabbit polyclonal antibodies couples to the enzyme horseradish peroxidase (HRP), found in the roots of horseradish. Also monoclonal HRP conjugates are often used for Western Blot.
• Additional conjugation
  HRP Conjugated
• French translation
  anticorps

• Gene target
  RUNX1   Ser266   Conjugated  
• Gene symbol
  RUNX1-IT1, RUNX1
• Short name
  Anti-RUNX1 Ser266
• Technique
  Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
• Isotype
  Immunoglobulin G (IgG)
• Label
  HRP
• Alternative name
  Anti-RUNX1 Ser266 PAb HRP
• Alternative technique
  antibodies
• Alternative to gene target
  runt-related transcription factor 1, AML1 and AML1-EVI-1 and AMLCR1 and CBFA2 and EVI-1 and PEBP2aB, RUNX1 and IDBG-2825 and ENSG00000159216 and 100506403,101928269,861, repressing transcription factor binding, nuclei, Runx1 and IDBG-177713 and ENSMUSG00000022952 and 12394, RUNX1 and IDBG-640443 and ENSBTAG00000004742 and 529631

Gene info

• Identity
  HGNC:16623
• Gene
  RUNX1-IT1
• Long gene name
  RUNX1 intronic transcript 1
• Synonyms gene
  • C21orf96
• Synonyms gene name
  • chromosome 21 open reading frame 96
  • RUNX1 intronic transcript 1 (non-protein coding)
• Synonyms
  • FLJ20856
• GenBank acession
  • AK024509
• Locus
  21q22.12
• Discovery year
  2003-10-01
• Entrez gene record
  80215
• Pubmed identfication
  • 32487998
• RefSeq identity
  • NR_026812
• Classification
  • Intronic transcripts

Gene info

• Identity
  HGNC:10471
• Gene
  RUNX1
• Long gene name
  RUNX family transcription factor 1
• Synonyms gene
  • AML1
  • CBFA2
• Synonyms gene name
  • acute myeloid leukemia 1
  • runt-related transcription factor 1
  • runt related transcription factor 1
• Synonyms
  • PEBP2A2
  • AMLCR1
• Synonyms name
  • aml1 oncogene
• GenBank acession
  • X79549
• Locus
  21q22.12
• Discovery year
  1991-08-20
• Entrez gene record
  861
• Pubmed identfication
  • 1427868
  • 7835892
• Classification
  • Runt-related transcription factors
• VEGA ID
  OTTHUMG00000086299
• Locus Specific Databases
  • LRG_482

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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