RUNX1 (Ser249) Antibody, Cy5.5 Conjugated

• Catalog number
  bs-3023R-Cy5.5
• Price
  Please ask
• Size
  0.1ml

• Long name
  RUNX1 (Ser249) Polyclonal Antibody, Cy5.5 Conjugated
• Category
  Conjugated Primary Antibodies
• Conjugation
  Cy5.5
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  RUNX1 Ser249
• Specificity
  This is a highly specific antibody against RUNX1 Ser249.
• Modification
  Phosphorylation
• Modification site
  Ser249
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic phosphopeptide derived from human RUNX1 around the phosphorylation site of Ser249 [QP(p-S)PP]
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Crossreactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Antigen background
  AML1/Runx1 binds DNA as a monomer and through the Runt domain. DNA binding is increased by heterodimerization with CBFB. Isoform AML1L can neither bind DNA nor heterodimerize and interferes with the transactivation activity of AML1/Runx1. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T cell receptor enhancers, LCK, IL3 and GMCSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. AML1/Runx1 is expressed in a wide variety of tissues and is expressed at the highest levels in thymus, bone marrow and peripheral blood. Defects in AML1/Runx1 are the cause of familial platelet disorder with associated myeloid malignancy, an autosomal dominant disease characterized by qualitative and quantitative platelet defects, and propensity to develop acute myelogenous leukemia.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
• Excitation Emission
  675nm/694nm
• Synonyms
  RUNX1 Ser249; p-RUNX1 Ser249; RUNX1 phospho S249; RUNX1 phospho Ser249; Acute myeloid leukemia 1; Acute myeloid leukemia 1 protein; alpha subunit core binding factor; AML 1; AML1 EVI 1; AML1; Aml1 oncogene; AMLCR 1; AMLCR1; CBFA 2; CBFA2; Core binding factor alpha 2 subunit; Core binding factor runt domain alpha subunit 2; EVI 1; EVI1; HGNC; Oncogene AML 1; PEA2 alpha; PEBP2 alpha B; PEBP2A2; PEBP2aB; Polyomavirus enhancer binding protein 2 alpha B subunit; Run1; Runt related transcription factor 1; RUNX 1; SL3 3 enhancer factor 1 alpha B subunit; SL3/AKV core binding factor alpha B subunit; RUNX1_HUMAN.
• Properties
  If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Cy5 antibodies are excited by the 650-nanometer wave of an argon laser and detected at a 670-nanometer captor.
• Additional conjugation
  Cy5.5, Cy5.5
• Conjugated
  These antibodies are excite for emission at 678nm and detected at a 694 nm wavelengths.
• French translation
  anticorps

• Gene target
  RUNX1   Ser249   Conjugated  
• Gene symbol
  RUNX1-IT1, RUNX1
• Short name
  Anti-RUNX1 Ser249
• Technique
  Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
• Isotype
  Immunoglobulin G (IgG)
• Label
  Cy5.5
• Alternative name
  Anti-RUNX1 Ser249 PAb Cy5.5
• Alternative technique
  antibodies
• Alternative to gene target
  runt-related transcription factor 1, AML1 and AML1-EVI-1 and AMLCR1 and CBFA2 and EVI-1 and PEBP2aB, RUNX1 and IDBG-2825 and ENSG00000159216 and 100506403,101928269,861, repressing transcription factor binding, nuclei, Runx1 and IDBG-177713 and ENSMUSG00000022952 and 12394, RUNX1 and IDBG-640443 and ENSBTAG00000004742 and 529631

Gene info

• Identity
  HGNC:16623
• Gene
  RUNX1-IT1
• Long gene name
  RUNX1 intronic transcript 1
• Synonyms gene
  • C21orf96
• Synonyms gene name
  • chromosome 21 open reading frame 96
  • RUNX1 intronic transcript 1 (non-protein coding)
• Synonyms
  • FLJ20856
• GenBank acession
  • AK024509
• Locus
  21q22.12
• Discovery year
  2003-10-01
• Entrez gene record
  80215
• Pubmed identfication
  • 32487998
• RefSeq identity
  • NR_026812
• Classification
  • Intronic transcripts

Gene info

• Identity
  HGNC:10471
• Gene
  RUNX1
• Long gene name
  RUNX family transcription factor 1
• Synonyms gene
  • AML1
  • CBFA2
• Synonyms gene name
  • acute myeloid leukemia 1
  • runt-related transcription factor 1
  • runt related transcription factor 1
• Synonyms
  • PEBP2A2
  • AMLCR1
• Synonyms name
  • aml1 oncogene
• GenBank acession
  • X79549
• Locus
  21q22.12
• Discovery year
  1991-08-20
• Entrez gene record
  861
• Pubmed identfication
  • 1427868
  • 7835892
• Classification
  • Runt-related transcription factors
• VEGA ID
  OTTHUMG00000086299
• Locus Specific Databases
  • LRG_482

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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