PRK1 (Thr774)/PRK2 (Thr816) Antibody, Cy3 Conjugated

• Catalog number
  bs-3347R-Cy3
• Price
  Please ask
• Size
  0.1ml

• Long name
  PRK1 (Thr774)/PRK2 (Thr816) Antibody, Cy3 Conjugated
• Category
  Conjugated Primary Antibodies
• Conjugation
  Cy3
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  PRK1 Thr774 + PRK2 Thr816
• Specificity
  This is a highly specific antibody against PRK1 Thr774 + PRK2 Thr816.
• Modification
  Phosphorylation
• Modification site
  Thr816
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic phosphopeptide derived from human PRK1 around the phosphorylation site of Thr774
• Gene ID number
  5585
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Crossreactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Antigen background
  Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) induces proliferation, migration, and fenestration in capillary endothelial cells derived from endocrine glands. EG-VEGF possesses an HIF-1 binding site; its expression is induced by hypoxia and restricted to the steroidogenic glands (ovary, testis, adrenal and placenta). Expression of EG-VEGF is often complementary to the expression of VEGF, suggesting that these molecules function in a coordinated manner. EG-VEGF is an example of a class of highly specific mitogens that act to regulate proliferation and differentiation of the vascular endothelium in a tissue-specific manner. It is expressed primarily in one type of tissue and acts selectively on one type of endothelium. EG-VEGF, possibly through binding to a G protein-coupled receptor, results in the activation of MAPK p44/42 and phosphatidylinositol 3-kinase signaling pathways, leading to proliferation, migration and survival of responsive endothelial cells .
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
• Excitation Emission
  512,550nm/570,615nm
• Synonyms
  Prokineticin-1/Endocrine-gland-derived vascular endothelial growth factor; PROK1; EGVEGF; PK1; EG-VEGF; PRK1.
• Properties
  If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser. 1 of the Anti-PRK1 Thr774 + PRK2 Thr816 can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC. This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy.
• Additional conjugation
  cy3 conjugation kit
• French translation
  anticorps

• Gene target
  PRK1   Thr774   PRK2   Thr816   Conjugated  
• Gene symbol
  PROK1, PKN2, PKN1
• Short name
  Anti-PRK1 Thr774 + PRK2 Thr816
• Technique
  Antibody, antibodies against human proteins, antibodies for, antibody Conjugates
• Isotype
  Immunoglobulin G (IgG)
• Label
  Cy3
• Alternative name
  Anti-PRK1 Thr774 + PRK2 Thr816 PAb Cy3
• Alternative technique
  antibodies

Gene info

• Identity
  HGNC:18454
• Gene
  PROK1
• Long gene name
  prokineticin 1
• Synonyms
  • PK1
  • PRK1
  • EGVEGF
• Synonyms name
  • black mamba toxin-related protein
  • mambakine
• GenBank acession
  • AF333024
• Locus
  1p13.3
• Discovery year
  2002-07-22
• Entrez gene record
  84432
• Pubmed identfication
  • 11259612
• RefSeq identity
  • NM_032414
• Classification
  • Receptor ligands
• VEGA ID
  OTTHUMG00000011569

Gene info

• Identity
  HGNC:9406
• Gene
  PKN2
• Long gene name
  protein kinase N2
• Synonyms gene
  • PRKCL2
• Synonyms gene name
  • protein kinase C-like 2
• Synonyms
  • PRK2
  • Pak-2
  • STK7
• Synonyms name
  • cardiolipin-activated protein kinase Pak2
• GenBank acession
  • U33052
• Locus
  1p22.2
• Discovery year
  1997-10-10
• Entrez gene record
  5586
• Pubmed identfication
  • 7988719
  • 7851406
• RefSeq identity
  • NM_006256
• Classification
  • C2 domain containing protein kinases
  • AGC family kinases
  • Small nucleolar RNA protein coding host genes
• VEGA ID
  OTTHUMG00000010074

Gene info

• Identity
  HGNC:9405
• Gene
  PKN1
• Long gene name
  protein kinase N1
• Synonyms gene
  • PRKCL1
• Synonyms gene name
  • protein kinase C-like 1
• Synonyms
  • DBK
  • PRK1
  • PKN
  • MGC46204
  • PAK1
• GenBank acession
  • S75546
• Locus
  19p13.12
• Discovery year
  1997-10-10
• Entrez gene record
  5585
• Pubmed identfication
  • 9570957
• RefSeq identity
  • NM_002741
  • NM_213560
• Classification
  • C2 domain containing protein kinases
  • AGC family kinases
• VEGA ID
  OTTHUMG00000039611

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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