BLM/Blooms Syndrome Protein Blm Antibody, FITC Conjugated

• Catalog number
  bs-12872R-FITC
• Price
  Please ask
• Size
  0.1ml

• Long name
  BLM/Blooms Syndrome Protein Blm Antibody, FITC Conjugated
• Category
  Conjugated Primary Antibodies
• Conjugation
  FITC
• Host Organism
  Rabbit (Oryctolagus cuniculus)
• Target Antigen
  BLM/Blooms Syndrome Protein Blm
• Specificity
  This is a highly specific antibody against BLM/Blooms Syndrome Protein Blm.
• Modification
  Unmodified
• Modification site
  None
• Clonality
  Polyclonal
• Clone
  Polyclonal antibody
• Concentration
  1ug per 1ul
• Source
  KLH conjugated synthetic peptide derived from human BLM/Blooms Syndrome Protein Blm
• Gene ID number
  641
• Tested applications
  IF(IHC-P)
• Recommended dilutions
  IF(IHC-P)(1:50-200)
• Crossreactivity
  Human, Mouse, Rat
• Crossreactive species details
  Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
• Antigen background
  Bloom’s syndrome is an autosomal recessive disorder characterized by pre- and post-natal growth deficiencies, sun sensitivity, immunodeficiency and a predisposition to various cancers. The gene responsible for Bloom’s syndrome, BLM, encodes a protein homologous to the RecQ helicase of E. coli and is mutated in most Bloom’s syndrome patients. One characteristic of Bloom’s syndrome is an increased frequency of sister chromatid exchange (SCE). BLM has been shown to unwind G4 DNA, and a failure of this function is thought to be responsible for the increased rate of SCE. BLM is known to be translocated to the nucleus, where its ATPase activity is stimulated by both single- and double-stranded DNA. Mutations in the yeast SGS1, a homolog of BLM, are known to cause mitotic hyperrecombination similiar to that observed in Bloom’s cells.
• Purification method
  This antibody was purified via Protein A.
• Storage conditions
  Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
• Excitation Emission
  494nm/518nm
• Synonyms
  BLM; BLM_HUMAN; Bloom Syndrome; Bloom syndrome protein; Bloom syndrome RecQ helicase like; BS; DNA Helicase; DNA helicase RecQ like type 2; MGC126616; MGC131618; MGC131620; RECQ 2; RECQ like; RecQ like type 2; RecQ protein like 3; RecQ Protein-like 3; RECQ-2; RECQ-Like; RecQ-like type 2; RECQ2; RECQL 2; RECQL 3; RECQL-2; RECQL-3; RECQL2; RECQL3; type 2.
• Properties
  If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS. When excited at 488 nanometers, FITC has a green emission that's usually collected at 530 nanometers, the FL1 detector of a FACSCalibur or FACScan. FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light. For fluorescent microscopy applications, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept. Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes.
• Additional conjugation
  Anti-FITC Antibody
• French translation
  anticorps

• Gene target
  BLM/Blooms   Syndrome   Protein   Blm   Conjugated  
• Gene symbol
  BLM
• Short name
  Anti-BLM/Blooms Syndrome Protein Blm
• Technique
  Antibody, FITC, antibodies against human proteins, antibodies for, antibody Conjugates, Fluorescein
• Isotype
  Immunoglobulin G (IgG)
• Label
  FITC
• Alternative name
  Anti-BLM/Blooms Syndrome Protein Blm PAb FITC
• Alternative technique
  antibodies, fluorescine
• Alternative to gene target
  Bloom syndrome, RecQ helicase-like, BS and RECQ2 and RECQL2 and RECQL3, BLM and IDBG-30365 and ENSG00000197299 and 641, hydrolase activity, nuclei, Blm and IDBG-195418 and ENSMUSG00000030528 and 12144, BLM and IDBG-629490 and ENSBTAG00000020301 and 534148
• Disease
  syndrome

Gene info

• Identity
  HGNC:1058
• Gene
  BLM
• Long gene name
  BLM RecQ like helicase
• Synonyms gene name
  • Bloom syndrome
  • Bloom syndrome RecQ like helicase
• Synonyms
  • BS
  • RECQL3
  • RECQ2
• GenBank acession
  • U39817
• Locus
  15q26.1
• Discovery year
  1992-11-06
• Entrez gene record
  641
• Pubmed identfication
  • 9388193
• Classification
  • RecQ like helicases
• VEGA ID
  OTTHUMG00000149834
• Locus Specific Databases
  • BLMbase: Mutation registry for Bloom Syndrome
  • LRG_20

MeSH Data

• Name
  Blotting, Western
• Concept
  Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
• Tree numbers
  • E05.196.401.143
  • E05.301.300.096
  • E05.478.566.320.200
  • E05.601.262
  • E05.601.470.320.200
• Qualifiers
  ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data

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