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Anti-BLM/Blooms Syndrome Protein Blm, ALEXA Fluor 594

  • Catalog number
    GENTObs-12872R-A594
  • Product name
    Anti-BLM/Blooms Syndrome Protein Blm, ALEXA Fluor 594
  • Size
    100 microliters
  • Short name
    Anti-BLM/Blooms Syndrome Protein Blm
  • Type
    Conjugated Primary Antibody
  • Conjugated with
    ALEXA FLUOR® 594
  • Host organism
    Rabbit (Oryctolagus cuniculus)
  • Target Protein Peptide
    BLM/Blooms Syndrome Protein Blm
  • Specificity
    This antibody reacts specifically with BLM/Blooms Syndrome Protein Blm
  • Modification
    No modification has been applied to this antibody
  • Modification site
    None
  • Clonality
    Polyclonal Antibody
  • Clone
    Polyclonal Antibodies
  • Isotype
    Immunoglobulin G (IgG)
  • Concentration
    1ug per 1ul
  • Subcellular locations
    N/A
  • Antigen Source
    KLH conjugated synthetic peptide derived from human BLM/Blooms Syndrome Protein Blm
  • Gene ID
    641
  • Swiss Prot
    N/A
  • Applications
    IF(IHC-P)
  • Applications with corresponding dilutions
    IF(IHC-P)(1:50-200)
  • Cross reactive species
    Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus)
  • Cross Reactive Species details
    No significant cross reactivity has been observed for this antibody for the tested species. However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species.
  • Background information
    Bloom’s syndrome is an autosomal recessive disorder characterized by pre- and post-natal growth deficiencies, sun sensitivity, immunodeficiency and a predisposition to various cancers. The gene responsible for Bloom’s syndrome, BLM, encodes a protein homologous to the RecQ helicase of E. coli and is mutated in most Bloom’s syndrome patients. One characteristic of Bloom’s syndrome is an increased frequency of sister chromatid exchange (SCE). BLM has been shown to unwind G4 DNA, and a failure of this function is thought to be responsible for the increased rate of SCE. BLM is known to be translocated to the nucleus, where its ATPase activity is stimulated by both single- and double-stranded DNA. Mutations in the yeast SGS1, a homolog of BLM, are known to cause mitotic hyperrecombination similiar to that observed in Bloom’s cells.
  • Purification method
    Purified by Protein A.
  • Storage
    Water buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
  • Excitation emission
    590nm/617nm
  • Synonyms
    BLM; BLM_HUMAN; Bloom Syndrome; Bloom syndrome protein; Bloom syndrome RecQ helicase like; BS; DNA Helicase; DNA helicase RecQ like type 2; MGC126616; MGC131618; MGC131620; RECQ 2; RECQ like; RecQ like type 2; RecQ protein like 3; RecQ Protein-like 3; RECQ-2; RECQ-Like; RecQ-like type 2; RECQ2; RECQL 2; RECQL 3; RECQL-2; RECQL-3; RECQL2; RECQL3; type 2.
  • Also known as
    BLM/Blooms Syndrome Protein Blm Antibody
  • Other name
    Anti-BLM/Blooms Syndrome Protein Blm
  • Advisory
    Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody, thus reducing its reactivity, specificity and sensitivity. For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube. Prior to use briefly centrifuge the vial to gather all the solution on the bottom.
  • Alternative to gene target
    • [ "Bloom syndrome, RecQ helicase-like", "BS and RECQ2 and RECQL2 and RECQL3", "BLM and IDBG-30365 and ENSG00000197299 and 641", "hydrolase activity", "nuclei", "Blm and IDBG-195418 and ENSMUSG00000030528 and 12144", "BLM and IDBG-629490 and ENSBTAG00000020301 and 534148" ]
  • Gene target
    BLM/Blooms Syndrome Protein Blm
    • Gene info
    Locus Specific Databases:BLMbase: Mutation registry for Bloom SyndromeLRG_20
  • Gene symbol
    BLM
  • isotype filter
    • Immunoglobulin G IgG
  • Label
    ALEXA FLUOR 594
  • label filter
    • ALEXA FLUOR 594
  • technique filter
    • anti-
    • anti
  • Technique
    anti-, anti, antibody to, antibodies
  • Alternative technique
    antibodies
  • Disease
    syndrome
  • disease filter
    • syndrome