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BLM/Blooms Syndrome Protein Blm Antibody, ALEXA FLUOR 594

  • Catalog number
    bs-12872R-A594
  • Product name
    BLM/Blooms Syndrome Protein Blm Antibody, ALEXA FLUOR 594
  • Size
    100ul
  • Short name
    Anti-BLM/Blooms Syndrome Protein Blm
  • Long name
    BLM/Blooms Syndrome Protein Blm Antibody, ALEXA FLUOR 594 Conjugated
  • Also known as
    Anti-BLM/Blooms Syndrome Protein Blm PAb ALEXA FLUOR 594
  • Category
    Conjugated Primary Antibodies
  • Conjugated with
    ALEXA FLUOR® 594
  • Host Organism
    Rabbit (Oryctolagus cuniculus)
  • Target Antigen
    BLM/Blooms Syndrome Protein Blm
  • Specificity
    This is a highly specific antibody against BLM/Blooms Syndrome Protein Blm.
  • Modification
    Unmodified
  • Modification Site
    None
  • Clonality
    Polyclonal
  • Clone
    Polyclonal antibody
  • Isotype
    Immunoglobulin G (IgG)
  • Concentration
    1ug per 1ul
  • Source
    This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human BLM/Blooms Syndrome Protein Blm
  • Gene ID Number
    641
  • Tested applications
    IF(IHC-P)
  • Recommended dilutions
    IF(IHC-P)(1:50-200)
  • Crossreactivity
    Human, Mouse, Rat
  • Cross reactive species details
    Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
  • Background of the antigen
    Bloom’s syndrome is an autosomal recessive disorder characterized by pre- and post-natal growth deficiencies, sun sensitivity, immunodeficiency and a predisposition to various cancers. The gene responsible for Bloom’s syndrome, BLM, encodes a protein homologous to the RecQ helicase of E. coli and is mutated in most Bloom’s syndrome patients. One characteristic of Bloom’s syndrome is an increased frequency of sister chromatid exchange (SCE). BLM has been shown to unwind G4 DNA, and a failure of this function is thought to be responsible for the increased rate of SCE. BLM is known to be translocated to the nucleus, where its ATPase activity is stimulated by both single- and double-stranded DNA. Mutations in the yeast SGS1, a homolog of BLM, are known to cause mitotic hyperrecombination similiar to that observed in Bloom’s cells.
  • Purification
    Purified by Protein A.
  • Storage conditions
    Store this antibody in aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Keep refrigerated at 2 to 8 degrees Celcius for up to one year.
  • Excitation emission
    590nm/617nm
  • Synonyms
    BLM; BLM_HUMAN; Bloom Syndrome; Bloom syndrome protein; Bloom syndrome RecQ helicase like; BS; DNA Helicase; DNA helicase RecQ like type 2; MGC126616; MGC131618; MGC131620; RECQ 2; RECQ like; RecQ like type 2; RecQ protein like 3; RecQ Protein-like 3; RECQ-2; RECQ-Like; RecQ-like type 2; RECQ2; RECQL 2; RECQL 3; RECQL-2; RECQL-3; RECQL2; RECQL3; type 2.
  • Alternative to gene target
    • [ "Bloom syndrome, RecQ helicase-like", "BS and RECQ2 and RECQL2 and RECQL3", "BLM and IDBG-30365 and ENSG00000197299 and 641", "hydrolase activity", "nuclei", "Blm and IDBG-195418 and ENSMUSG00000030528 and 12144", "BLM and IDBG-629490 and ENSBTAG00000020301 and 534148" ]
  • Gene target
    BLM/Blooms Syndrome Protein Blm
    • Gene info
    Locus Specific Databases:BLMbase: Mutation registry for Bloom SyndromeLRG_20
  • Gene symbol
    BLM
  • isotype filter
    • Immunoglobulin G IgG
  • Label
    ALEXA FLUOR 594
  • label filter
    • ALEXA FLUOR 594
  • technique filter
    • Antibody
  • Technique
    Antibody, antibodies against human proteins, antibodies for
  • Alternative technique
    antibodies
  • Disease
    syndrome
  • disease filter
    • syndrome