IGF-BP1 Protein

Storage

For short term storage IGF-BP1 Protein may be kep at +4 deg. C. For long term storage keep the aliquoted vials frozen at -20 degrees Celsius.
Tips

Due to handling and transportation, small amounts of the IGF-BP1 Protein may get caught on the walls or seal of the vials. Prior to use briefly rund the vial(s) through a centrifuge to collect all of the content on the bottom. Avoid freezing and thawing the vials numerous times as such cycles may denaturate the peptide chains and influence the item's performance.
Description

IGF-I, IGF-II, insulin-like growth factors -1 and -2 are important regulators of signaling that mediates growth and metabolism in cells. Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades.

Gene target

BP1 Protein
Gene symbol

SIGMAR1, EIF4EBP1, REXO1, DLX4, GORAB, ATF2, NAE1, TSPOAP1, SIGLEC6
Short name

IGF-BP1 Protein
Technique

IGF, igfs
Alternative name

IGF-BP1 peptide
Alternative technique

igfs

Identity

HGNC:3288
Gene

EIF4EBP1
Long gene name

eukaryotic translation initiation factor 4E binding protein 1
Synonyms
- PHAS-I
- 4E-BP1
Synonyms name
- phosphorylated heat- and acid-stable protein regulated by insulin 1
Locus

8p11.23
Discovery year

1996-10-26
Entrez gene record

1978
Pubmed identfication
- 7935836
RefSeq identity
- NM_004095
VEGA ID

OTTHUMG00000164012

Identity

HGNC:24616
Gene

REXO1
Long gene name

RNA exonuclease 1 homolog
Synonyms gene
- TCEB3BP1
Synonyms gene name
- transcription elongation factor B polypeptide 3 binding protein 1
- REX1, RNA exonuclease 1 homolog (S. cerevisiae)
Synonyms
- EloA-BP1
- KIAA1138
Synonyms name
- elongin A binding protein 1
GenBank acession
- AB032964
Locus

19p13.3
Discovery year

2004-01-16
Entrez gene record

57455
Pubmed identfication
- 10574461
RefSeq identity
- NM_020695
Classification
- MicroRNA protein coding host genes
- Exonucleases
VEGA ID

OTTHUMG00000179991

Identity

HGNC:784
Gene

ATF2
Long gene name

activating transcription factor 2
Synonyms gene
- CREB2
Synonyms gene name
- cAMP responsive element binding protein 2
Synonyms
- TREB7
- CRE-BP1
- HB16
GenBank acession
- X15875
Locus

2q31.1
Discovery year

1991-08-01
Entrez gene record

1386
Pubmed identfication
- 1833307
- 1838349
RefSeq identity
- NM_001880
Classification
- Basic leucine zipper proteins
- MicroRNA protein coding host genes
VEGA ID

OTTHUMG00000132424

Identity

HGNC:10875
Gene

SIGLEC6
Long gene name

sialic acid binding Ig like lectin 6
Synonyms gene
- CD33L
- CD33L1
Synonyms gene name
- sialic acid binding Ig-like lectin 6
Synonyms
- OB-BP1
- SIGLEC-6
- CD327
GenBank acession
- D86358
Locus

19q13.41
Discovery year

1996-12-17
Entrez gene record

946
Pubmed identfication
- 9465907
RefSeq identity
- NM_001245
Classification
- I-set domain containing
- Sialic acid binding Ig like lectins
- V-set domain containing
- CD molecules
VEGA ID

OTTHUMG00000133571