IGF II protein

Category

Proteins
Antibody Subtype

Recombinant Proteins
Area of research

Cytokines & Growth Factors
Reactivity

Human
Type of protein

Recombinant
Expression System

Escherichia coli
Grade Purity

Grater than 98% pure
Method of Purification

IGF II protein was purified using a a proprietary chromatographic technique.
Form Buffer

Provided in lyophilized form with no additives
Storage

Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.
Shipping conditions

Blue Ice
Bioactivity

The ED50 as determined by competitive binding against plasma-derived IGF-II to human placental membranes is < 10 ng/ml, corresponding to a specific activity of > 1 x 10^6 units/mg
URL
More info
Description

IGF-I, IGF-II, insulin-like growth factors -1 and -2 are important regulators of signaling that mediates growth and metabolism in cells. Insulin-like growth factor -1 shares structural homology with proinsulin and is mainly produced by liver. IGF-1 acts via specific receptor, IGF-1R, a heterodimeric tyrosine kinase receptor that signals to various second messenger pathways such as MAPK, Raf/Ras and PI3K cascades.

Identity

HGNC:1460
Gene

CAMK2A
Long gene name

calcium/calmodulin dependent protein kinase II alpha
Synonyms gene
- CAMKA
Synonyms gene name
- calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha
Synonyms
Synonyms name
GenBank acession
- AB023185
Locus

5q32
Discovery year

1993-11-24
Entrez gene record

815
Pubmed identfication
- 10231032
- 3475713
RefSeq identity
- NM_015981
Classification
- Calmodulin dependent protein kinases
VEGA ID

OTTHUMG00000134281