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c-Kit-N Terminal His Tag - Active Enzyme

c-Kit-N Terminal His Tag - Active Enzyme is available 1 time from Nordc labs

X1760E | c-Kit-N Terminal His Tag - Active Enzyme size: 10 μg | 507.88 USD

Catalog number X1760E
Supplier nordc
Price 507.88 USD
Size 10 μg
Category Proteins & Peptides
Long description C-Kit is the receptor tyrosine kinase for stem cell factor (SCF) and is a member of the subfamily that includes PDGF, CSF-1 and FLT-3/flk-2 receptors . It plays critical controlling roles in a number of cell types such as hematopoietic stem cells, mast cells, melanocytes and germ cells . Upon binding with its ligand, c-Kit receptors are induced undergoing dimerization/ oligomerization and autophosphorylation. Activation of c-Kit results in the recruitment and tyrosine phosphorylation of downstream SH2-containing signaling components including PLCgamma, p85 subunit of PI3 kinase, SHP2 and CrkL, which links c-Kit directly to various cell signaling pathways. Molecular lesions that impair the kinase activity of c-Kit are associated with a variety of developmental disorders , while mutations that constitutively activate c-Kit can lead to pathogenesis of mastocytosis and gastrointestinal stromal tumors . Tyrosine 719 is located in the kinase insert region of the catalytic domain. c-Kit phosphorylated at Tyr719 binds to the p85 subunit of PI3 kinase in vitro and in vivo (7).
Antibody come from Rabbit polyclonal Caspase-4 antibody was raised against a 15 amino acid peptide from near the center of human Caspase-4.
Other description Provided as solution in phosphate buffered saline with 0.02% sodium azide.
Clone not specified
Antigen-antibody binding interaction c-Kit-N Terminal His Tag - Active Enzyme
Antibody is raised in Sf9 cells
Antibody's reacts with Human
Antibody's reacts with these species This antibody doesn't cross react with other species
Antibody's specificity No Data Available
Application Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Antibody's suited for Casp-4 (IN) antibody can be used for the detection of Caspase-4 by Western blot at 2 µg/ml. Depending on cell lines or tissues used, other cleavage products may be observed. Optimal concentration should be evaluated by serial dilutions.
Storage -20ºC
Relevant references 1) Martinon F and Tschopp J. Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases Cell 2004; 117:561-74._x000B_2) Kuida K, Lippke JA, Ku G, et al. Altered cytokine export and apoptosis in mice deficient in interleukin-1 converting enzyme.Science 1995; 267:2000-3._x000B_3) Gracie JA, Robertson SE, and McInnes IB. Interleukin-18. J. Leukoc. Biol. 2003; 73:213-224._x000B_4) Kamens J, Paskind M, Hugunin M, et al. Identification and characterization of ICH-2, a novel member of the interleukin-1 converting enzyme family of cysteine proteases.J. Biol. Chem. 1995; 270:15250-6.
Protein number see ncbi
Warnings This product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. This datasheet is as accurate as reasonably achievable, but Nordic-MUbio accepts no liability for any inaccuracies or omissions in this information.
Description Enzymes are cleaving the substrate. If the substrate is DNA they are called restriction enzymes. Activating enzymes will cut off the domain that is biological active to become functional.
Conjugation histidine
Gene targetc-Kit-N Terminal His Tag Active
Short name c-Kit-N Terminal His Tag - Active Enzyme
Technique Enzyme
Isotype not specified
Label unlabeled
Alternative name c-reagent-N Terminal histidine detection labelled - functionnal Enzyme
Alternative technique enzymes
Alternative to gene target v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, C-Kit and CD117 and PBT and SCFR, KIT and IDBG-18980 and ENSG00000157404 and 3815, transferase activity, Extracellular, Kit and IDBG-172083 and ENSMUSG00000005672 and 16590, KIT and IDBG-642326 and ENSBTAG00000002699 and 280832
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