Human LDL Receptor/LDLR standard

Reactivity

Human
Assay Type

Sandwich ELISA
Properties

Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Description

The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

Gene target

LDL Receptor/LDLR
Gene symbol

LDLR, LDLR-AS1, PLA2G7
Short name

LDL Receptor/LDLR standard
Technique

Standard, standards
Species

Human, Humans
Alternative name

H. sapiens LDL Receptor/low density lipoprotein receptor reference
Alternative technique

standards
Alternative to gene target

low density lipoprotein receptor, FH and FHC and LDLCQ2, LDLR and IDBG-28808 and ENSG00000130164 and 3949, very-low-density lipoprotein particle receptor activity, Cell surfaces, Ldlr and IDBG-141358 and ENSMUSG00000032193 and 16835, LDLR and IDBG-643476 and ENSBTAG00000012314 and 281276

Identity

HGNC:6547
Gene

LDLR
Long gene name

low density lipoprotein receptor
Synonyms
- LDLCQ2
Synonyms name
- familial hypercholesterolemia
GenBank acession
- AY114155
Locus

19p13.2
Discovery year

1986-01-01
Entrez gene record

3949
Classification
- Low density lipoprotein receptors
- MicroRNA protein coding host genes
VEGA ID

OTTHUMG00000171935
Locus Specific Databases

Identity

HGNC:9040
Gene

PLA2G7
Long gene name

phospholipase A2 group VII
Synonyms gene name
- phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
Synonyms
- PAFAH
- LDL-PLA2
GenBank acession
- U20157
Locus

6p12.3
Discovery year

1999-09-20
Entrez gene record

7941
Pubmed identfication
- 7700381
- 8624782
Classification
- Phospholipases
VEGA ID

OTTHUMG00000014789