LDLR (Low-density Lipoprotein Receptor, LDL Receptor) (APC)[LDLR]

Products_type

Antibody
Reactivity

Human
Description

High and low density proteins are supplied by MyBioSource in volumes of 1. Other densities are possible. The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. However, sometimes in pharmacology, the term is also used to include other proteins that are drug-targets, such as enzymes, transporters and ion-channels.

Gene target

LDLR Lipoprotein Receptor LDL Receptor APC [LDLR]
Gene symbol

LDLR, LDLR-AS1, PLA2G7, APC
Short name

LDLR ( - Lipoprotein Receptor, LDL Receptor) (APC)[LDLR]
Host

Mouse
Label

APC
Alternative name

low density lipoprotein receptor (Low-density Lipoprotein Receptor, LDL Receptor) (adenomatous polyposis coli)[low density lipoprotein receptor]
Alternative to gene target

low density lipoprotein receptor, FH and FHC and LDLCQ2, LDLR and IDBG-28808 and ENSG00000130164 and 3949, very-low-density lipoprotein particle receptor activity, Cell surfaces, Ldlr and IDBG-141358 and ENSMUSG00000032193 and 16835, LDLR and IDBG-643476 and ENSBTAG00000012314 and 281276

Identity

HGNC:6547
Gene

LDLR
Long gene name

low density lipoprotein receptor
Synonyms
- LDLCQ2
Synonyms name
- familial hypercholesterolemia
GenBank acession
- AY114155
Locus

19p13.2
Discovery year

1986-01-01
Entrez gene record

3949
Classification
- Low density lipoprotein receptors
- MicroRNA protein coding host genes
VEGA ID

OTTHUMG00000171935
Locus Specific Databases

Identity

HGNC:9040
Gene

PLA2G7
Long gene name

phospholipase A2 group VII
Synonyms gene name
- phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
Synonyms
- PAFAH
- LDL-PLA2
GenBank acession
- U20157
Locus

6p12.3
Discovery year

1999-09-20
Entrez gene record

7941
Pubmed identfication
- 7700381
- 8624782
Classification
- Phospholipases
VEGA ID

OTTHUMG00000014789

Identity

HGNC:583
Gene

APC
Long gene name

APC regulator of WNT signaling pathway
Synonyms gene name
- adenomatosis polyposis coli
- adenomatous polyposis coli
- APC, WNT signaling pathway regulator
Synonyms
- DP2
- DP3
- DP2.5
- PPP1R46
Synonyms name
- protein phosphatase 1, regulatory subunit 46
GenBank acession
- M74088
Locus

5q22.2
Discovery year

1986-01-01
Entrez gene record

324
Pubmed identfication
- 1651563
RefSeq identity
- NM_000038
Classification
- Protein phosphatase 1 regulatory subunits
- Armadillo repeat containing
VEGA ID

OTTHUMG00000128806
Locus Specific Databases