MLH1 (Human Mul L Homolog, Familial Nonpolyposis Colin Cancer Type 2, COCA2, Colon Cancer Type 2, DNA Mismatch Repair Protein Mlh1, FCC2, hMLH1, HNPCC, HNPCC2, MGC5172, MutL Homolog 1, MutL Homolog 1 Colon Cancer Nonpolyposis Type 2, MutL Protein Homolog Antibody

  • Catalog number
    GEN607478
  • Price
    Please ask
  • Size
    6 ml
  • Also known as
    MLH1
  • Other names
    Mlh1; N/A; CG11482 gene product from transcript CG11482-RA; Mlh1; CG11482-PA; Mlh1-PA; N/A; N/A
  • Category
    Antibodies
  • Subcategory
    Mnoclonal antibodies
  • Gene name
    Mlh1; N/A; CG11482; DmelCG11482; dmlh-1; dmlh1; N/A
  • Gene name synonims
    Mlh1; N/A; CG11482; DmelCG11482; dmlh-1; dmlh1; N/A
  • Other gene names
    Mlh1; N/A; CG11482; DmelCG11482; dmlh-1; dmlh1; N/A
  • Clonality
    Monoclonal
  • Immunoglobulin isotype
    IgG1
  • Clone
    8L780
  • Host organism
    Mouse (Mus musculus)
  • Source organism
    Human (Homo sapiens)
  • Species reactivity
    Hamster, Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
  • Specificity and cross reactivity
    Recognizes the human and mouse MLH1 (80-85kDa. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC). MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair. This antibody cross reacts with human, hamster and rat Species Crossreactivity: Thsi antibody is reactive against human, mouse, hamster and rat.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
  • Purification method
    Affinity Purified by Protein A affinity chromatography.
  • Form Appearance
    N/A
  • Concentration
    N/A
  • Storage and shipping
    Store the antibody at +4 degrees Celsius for short term storage.. For long-term storage and to avoid repeated freezing and thawing, aliquot For optimal long term storage, the antibody should be kept at -20 degrees Celsius. Aliquots are stable for at least 12 months the antibody should be stored at -20 degrees Celsius.. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
  • Tested applications
    Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
  • Properties
    If you buy Antibodies supplied by MBS Monoclonals they should be stored frozen at - 24°C for long term storage and for short term at + 5°C. Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
  • French translation
    anticorps
  • Gene target
    MLH1   Mul   Homolog   Familial   Nonpolyposis   Colin   Cancer   COCA2   Colon   Cancer   DNA   Mismatch   Repair   Protein   Mlh1   FCC2   hMLH1   HNPCC   HNPCC2   MGC5172   MutL   Homolog   MutL   Homolog   Colon   Cancer   Nonpolyposis   MutL   Protein   Homolog  
  • Gene symbol
    MLH1, MSH2, PRKDC, HLA-DOA
  • Short name
    MLH1 ( Mul L Homolog, Familial Nonpolyposis Colin Cancer 2, COCA2, Colon Cancer 2, DNA Mismatch Repair Protein Mlh1, FCC2, hMLH1, HNPCC, HNPCC2, MGC5172, MutL Homolog 1, MutL Homolog 1 Colon Cancer Nonpolyposis 2, MutL Protein Homolog Antibody
  • Technique
    Antibody, dna, antibodies against human proteins, antibodies for
  • Species
    Human, Humans
  • Alternative name
    Anti-MLH1 (Human Mul L Homolog, Familial Nonpolyposis Colin Cancer Type 2, COCA2, Colon Cancer Type 2, DNA Mismatch Repair Protein Mlh1, FCC2, hMLH1, HNPCC, HNPCC2, MGC5172, MutL Homolog 1, MutL Homolog 1 Colon Cancer Nonpolyposis Type 2, MutL Protein Homolog
  • Alternative technique
    antibodies
  • Alternative to gene target
    mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli), COCA2 and FCC2 and hMLH1 and HNPCC and HNPCC2, MLH1 and IDBG-24600 and ENSG00000076242 and 4292, structure-specific DNA binding, nuclei, Mlh1 and IDBG-202755 and ENSMUSG00000032498 and 17350, MLH1 and IDBG-644253 and ENSBTAG00000016758 and 533652
  • Tissue
    colon
  • Disease
    cancer
Gene info
Gene info
Gene info
Gene info
MeSH Data
  • Name
    Blotting, Western
  • Concept
    Scope note: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
  • Tree numbers
    • E05.196.401.143
    • E05.301.300.096
    • E05.478.566.320.200
    • E05.601.262
    • E05.601.470.320.200
  • Qualifiers
    ethics, trends, veterinary, history, classification, economics, instrumentation, methods, standards, statistics & numerical data
Product images
Similar products
Filters
MLH1 Mul L Homolog Familial Nonpolyposis Colin Cancer 2 COCA
Contact
Back
Chat with gentaur.com employee