MLH1 (Human Mul L Homolog, Familial Nonpolyposis Colin Cancer Type 2, COCA2, Colon Cancer Type 2, DNA Mismatch Repair Protein Mlh1, FCC2, hMLH1, HNPCC, HNPCC2, MGC5172, MutL Homolog 1, MutL Homolog 1 Colon Cancer Nonpolyposis Type 2, MutL Protein Homolog
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Catalog numberGEN607478
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Price808.06 USD
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Size6 ml
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Also known asMLH1
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Other namesMlh1; N/A; CG11482 gene product from transcript CG11482-RA; Mlh1; CG11482-PA; Mlh1-PA; N/A; N/A
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CategoryAntibodies
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SubcategoryMnoclonal antibodies
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Gene nameMlh1; N/A; CG11482; DmelCG11482; dmlh-1; dmlh1; N/A
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Gene name synonimsMlh1; N/A; CG11482; DmelCG11482; dmlh-1; dmlh1; N/A
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Other gene namesMlh1; N/A; CG11482; DmelCG11482; dmlh-1; dmlh1; N/A
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ClonalityMonoclonal
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Immunoglobulin isotypeIgG1
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Clone8L780
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Host organismMouse (Mus musculus)
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Source organismHuman (Homo sapiens)
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Species reactivityHamster, Human (Homo sapiens), Mouse (Mus musculus), Rat (Rattus norvegicus); Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby.
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Specificity and cross reactivityRecognizes the human and mouse MLH1 (80-85kDa. The repair of mismatch DNA is essential to maintaining the integrity of genetic information over time. An alteration of microsatellite repeats is the result of slippage owing to strand misalignment during DNA replication and is referred to as microsatellite instability (MSI). These defects in DNA repair pathways have been related to human carcinogenesis. The importance of mismatch repair genes became apparent with the identification of the genetic basis for hereditary nonpolyposis colon cancer (HNPC). MSH-2 is involved in the initial cognition of mismatch nucleotides during the replication mismatch repair process. It is thought that after MSH2 binds to a mismatched DNA duplex it is joined by a heterodimer of MLH1 and PMSH, which together help facilitate the later steps in mismatch repair. This antibody cross reacts with human, hamster and rat Species Crossreactivity: Thsi antibody is reactive against human, mouse, hamster and rat.; Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited. This particular antibody might cross react with speacies outside of the listed ones.
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Purification methodAffinity Purified by Protein A affinity chromatography.
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Form AppearanceN/A
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ConcentrationN/A
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Storage and shippingStore the antibody at +4 degrees Celsius for short term storage.. For long-term storage and to avoid repeated freezing and thawing, aliquot For optimal long term storage, the antibody should be kept at -20 degrees Celsius. Aliquots are stable for at least 12 months the antibody should be stored at -20 degrees Celsius.. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
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Tested applicationsImmunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
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PropertiesHuman proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
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Gene target
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Gene symbolMLH1, MSH2, PRKDC, HLA-DOA
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Short nameMLH1 ( Mul L Homolog, Familial Nonpolyposis Colin Cancer 2, COCA2, Colon Cancer 2, DNA Mismatch Repair Protein Mlh1, FCC2, hMLH1, HNPCC, HNPCC2, MGC5172, MutL Homolog 1, MutL Homolog 1 Colon Cancer Nonpolyposis 2, MutL Protein Homolog
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Techniquedna
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SpeciesHuman, Humans
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Alternative nameAnti-MLH1 (Human Mul L Homolog, Familial Nonpolyposis Colin Cancer Type 2, COCA2, Colon Cancer Type 2, DNA Mismatch Repair Protein Mlh1, FCC2, hMLH1, HNPCC, HNPCC2, MGC5172, MutL Homolog 1, MutL Homolog 1 Colon Cancer Nonpolyposis Type 2, MutL Protein Homolog
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Alternative to gene targetmutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli), COCA2 and FCC2 and hMLH1 and HNPCC and HNPCC2, MLH1 and IDBG-24600 and ENSG00000076242 and 4292, structure-specific DNA binding, nuclei, Mlh1 and IDBG-202755 and ENSMUSG00000032498 and 17350, MLH1 and IDBG-644253 and ENSBTAG00000016758 and 533652
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Tissuecolon
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Diseasecancer
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Gene info
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Identity
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Gene
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Long gene namemutL homolog 1
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Synonyms gene
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Synonyms gene name
- mutL (E. coli) homolog 1 (colon cancer, nonpolyposis type 2)
- mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)
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Synonyms
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GenBank acession
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Locus
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Discovery year1993-11-24
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- MutL homologs
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namemutS homolog 2
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Synonyms gene
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Synonyms gene name
- mutS (E. coli) homolog 2 (colon cancer, nonpolyposis type 1)
- mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)
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Synonyms
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Synonyms name
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GenBank acession
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Locus
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Discovery year1993-07-28
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Entrez gene record
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Pubmed identfication
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Classification
- MutS homologs
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene nameprotein kinase, DNA-activated, catalytic subunit
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Synonyms gene
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Synonyms gene name
- protein kinase, DNA-activated, catalytic polypeptide
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Synonyms
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Synonyms name
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Locus
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Discovery year1993-11-09
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- Armadillo like helical domain containing
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VEGA ID
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Locus Specific Databases
Gene info
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Identity
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Gene
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Long gene namemajor histocompatibility complex, class II, DO alpha
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Synonyms gene
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Synonyms
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GenBank acession
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Locus
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Discovery year2001-06-22
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Entrez gene record
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Pubmed identfication
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RefSeq identity
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Classification
- C1-set domain containing
- Histocompatibility complex
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VEGA ID
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Locus Specific Databases
MeSH Data
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Name
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ConceptScope note: A technique which uses synthetic oligonucleotides to direct the cell's inherent DNA repair system to correct a mutation at a specific site in an episome or chromosome.
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Tree numbers
- E02.095.301.500
- E05.393.420.301.500
- E05.393.420.601.575.500
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Qualifierslegislation & jurisprudence, ethics, mortality, psychology, trends, veterinary, history, classification, economics, instrumentation, methods, nursing, standards, adverse effects, statistics & numerical data