HDM Inhibitor, 2,4-PDCA
-
Catalog number2304-500
-
PricePlease ask
-
Size500 mg
-
-
Alternative_name2,4-Pyridinecarboxylic acid, monohydrate
-
DescriptionA histone-lysine demethylase (HKDM) inhibitor. Inhibits JARID1 proteins with an IC₅₀ values of 4.3 µM for JARID1B and 4.1 µM for JARID1A. 2, 4-PDCA does not inhibit UTX even at 10 µM.
-
CAS Number207671-42-9
-
Structure AvailableYes
-
Peptide sequenceNo
-
Salt FormNo
-
Molecular FormulaC₇H₅N₄ .H₂O
-
Molecular Weight185.13
-
Cell PermeableYes
-
Purity≥98% by titration
-
SolubilitiesDMSO
-
HandlingProtect from air and light
-
Tag LineA histone lysine demethylase (HKDM) inhibitor
-
Storage Condition-20 ̊C
-
Shipping Conditiongel pack
-
Shelf Life36 months
-
MDL NumberMFCD00149413
-
PubChem CID10365
-
SMILESC1=CN=C(C=C1C(=O)O)C(=O)O
-
InChiInChI=1S/C7H5NO4/c9-6(10)4-1-2-8-5(3-4)7(11)12/h1-3H,(H,9,10)(H,11,12)
-
InChi KeyMJIVRKPEXXHNJT-UHFFFAOYSA-N
-
MSDS AvailableYes
-
Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
-
Gene target
-
Gene symbolMIR1302-4, PIRC18, PIRC16, SNORD114-4, IGKV2OR2-4, MIR941-4, PIRC19, PIRC17
-
Short nameHDM Inhibitor, 2 4-PDCA
-
Alternative nameHDM suppressor, 2,4-PDCA
-
Gene info
-
Identity
-
Gene
-
Long gene namemicroRNA 1302-4
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year2008-11-03
-
Entrez gene record
-
RefSeq identity
-
Classification
- MicroRNA MIR1302 family
Gene info
-
Identity
-
Gene
-
Long gene namepiwi-interacting RNA cluster 18
-
Locus
-
Discovery year2009-11-05
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Piwi-interacting RNA clusters
Gene info
-
Identity
-
Gene
-
Long gene namepiwi-interacting RNA cluster 16
-
Locus
-
Discovery year2009-11-05
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Piwi-interacting RNA clusters
Gene info
-
Identity
-
Gene
-
Long gene namesmall nucleolar RNA, C/D box 114-4
-
Synonyms
-
Locus
-
Discovery year2006-09-26
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Small nucleolar RNAs, C/D box
Gene info
-
Identity
-
Gene
-
Long gene nameimmunoglobulin kappa variable 2/OR2-4 (pseudogene)
-
Synonyms gene name
- immunoglobulin kappa variable 2/OR2-4
- immunoglobulin kappa variable 2/OR2-4 pseudogene
-
Synonyms
-
GenBank acession
-
Locus
-
Discovery year2000-04-18
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Immunoglobulin kappa (IGK) orphons
Gene info
-
Identity
-
Gene
-
Long gene namemicroRNA 941-4
-
Synonyms gene
-
Synonyms
-
Locus
-
Discovery year2007-10-24
-
Entrez gene record
-
RefSeq identity
-
Classification
- MicroRNAs
Gene info
-
Identity
-
Gene
-
Long gene namepiwi-interacting RNA cluster 19
-
Locus
-
Discovery year2009-11-05
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Piwi-interacting RNA clusters
Gene info
-
Identity
-
Gene
-
Long gene namepiwi-interacting RNA cluster 17
-
Locus
-
Discovery year2009-11-05
-
Entrez gene record
-
Pubmed identfication
-
Classification
- Piwi-interacting RNA clusters