Jumonji HDM Inhibitor, PBIT
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Catalog number
2475-5
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Price
Please ask
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Size
5 mg
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Alternative_name
2-4(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one
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Description
PBIT is a potent, cell-permeable inhibitor of Jumonji histone demethylase (JHDM). Innhibits JARID1B (also known as KDM5B or PLU1) with an IC₅₀ of about 3 μm in vitro. PBIT treatment inhibits removal of H3K4me3 by JARID1B in cells and inhibits proliferation of cells expressing higher levels of JARID1B.
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CAS Number
2514-30-9
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₁₄H₁₁NOS
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Molecular Weight
241.31
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Solubilities
DMSO (~50 mg/ml)
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Handling
Protect from air and light
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Tag Line
A potent jumonji HDM inhibitor
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
24 months
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MDL Number
MFCD05856231
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PubChem CID
935415
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SMILES
CC1=CC=C(C=C1)N2C(=O)C3=CC=CC=C3S2
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InChi
InChI=1S/C14H11NOS/c1-10-6-8-11(9-7-10)15-14(16)12-4-2-3-5-13(12)17-15/h2-9H,1H3
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InChi Key
KRXMYBAZKJBJAB-UHFFFAOYSA-N
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MSDS Available
Yes
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Short name
Jumonji HDM Inhibitor, PBIT
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Alternative name
Jumonji HDM suppressor, PBIT
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