Jumonji HDM Inhibitor, JIB-04
-
Catalog number2474-5
-
PricePlease ask
-
Size5 mg
-
-
Alternative_name5-Chloro-2-[(E)-2-[phenyl(pyridin-2-yl)methylidene]hydrazin-1-yl]pyridine; NSC693627
-
DescriptionJIB-04 (E-isomer) is a potent, cell-permeable inhibitor of Jumonji histone demethylases in vitro and in vivo. (In vitro IC₅₀ values are 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively). JIB-04 is not a competitive inhibitor of α-ketoglutarate ; it selectively inhibits viability of several human cancer cell lines with little toxicity towards normal cells, and also diminishes tumor growth in xenograft mouse models.
-
CAS Number199596-05-9
-
Structure AvailableYes
-
Salt FormNo
-
Molecular FormulaC₁₇H₁₃ClN₄
-
Molecular Weight308.76
-
Cell PermeableYes
-
Purity≥98% by HPLC
-
SolubilitiesDMSO (~20 mg/ml)
-
HandlingProtect from air and light
-
Tag LineA potent jumonji HDM inhibitor
-
Storage Condition-20°C
-
Shipping Conditiongel pack
-
Shelf Life24 months
-
PubChem CID6519698
-
SMILESC1=CC=C(C=C1)C(=NNC2=NC=C(C=C2)Cl)C3=CC=CC=N3
-
InChiInChI=1S/C17H13ClN4/c18-14-9-10-16(20-12-14)21-22-17(13-6-2-1-3-7-13)15-8-4-5-11-19-15/h1-12H,(H,20,21)/b22-17+
-
InChi KeyYHHFKWKMXWRVTJ-OQKWZONESA-N
-
MSDS AvailableYes
-
Additional descriptionTissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
-
Gene target
-
Gene symbolYARS2, HCG4P4
-
Short nameJumonji HDM Inhibitor, JIB-04
-
Alternative nameJumonji HDM suppressor, JIB-04
-
Gene info
-
Identity
-
Gene
-
Long gene nametyrosyl-tRNA synthetase 2
-
Synonyms gene name
- tyrosyl-tRNA synthetase 2, mitochondrial
-
Synonyms
-
Synonyms name
-
GenBank acession
-
Locus
-
Discovery year2005-06-28
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity
-
Classification
- Aminoacyl tRNA synthetases, Class I
-
VEGA ID
Gene info
-
Identity
-
Gene
-
Long gene nameHLA complex group 4 pseudogene 4
-
Synonyms
-
Synonyms name
-
Locus
-
Discovery year2003-09-01
-
Entrez gene record
-
Pubmed identfication
-
RefSeq identity