Beta-Secretase Inhibitor II

• Catalog number
  7502-1
• Price
  Please ask
• Size
  1 mg

• Description
  A potent, cell permeable and reversible inhibitor of β-secretase that corresponds to the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Aβtotal (IC₅₀ = 700 nM) and Aβ1-42 (IC₅₀ = 2.5 µM) in CHO cells stably transfected with wild-type APP751.
• Structure Available
  No
• Peptide sequence
  Z-Val-Leu-Leu--CHO
• Salt Form
  No
• Molecular Formula
  C₂₅H₃₉N₃O₅
• Molecular Weight
  461.6
• Cell Permeable
  Yes
• Purity
  ≥95% by HPLC
• Solubilities
  DMSO
• Handling
  Protect from air and moisture
• Tag Line
  A beta-secretase inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  12 months
• PubChem CID
  10253763
• PubChem CID Link
• SMILES
  CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(C(C)C)NC(=O)OCC1=CC=CC=C1
• InChi
  239-200(315)150(93-258)251-190(305)143(82-112-90-215-95-219-112)248-203
• InChi Key
  YHUAFMGVVANYBT-FKBYEOEOSA-N
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  Beta-Secretase   Inhibitor  
• Short name
  Beta-Secretase Inhibitor II
• Alternative name
  b-Secretase suppressor II

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