mTOR Inhibitor, WYE-28

• Catalog number
  2255-500
• Price
  Please ask
• Size
  500 ug

• Alternative_name
  4-(6-{4-[3-(4-Hydroxymethyl-phenyl)-ureido]-phenyl}-4-morpholin-4-yl-pyrazolo[3,4-d]pyrimidin-1-yl)-piperidine-1-carboxylic acid methyl ester
• Description
  Cell-permeable. A potent, selective, and ATP-competitive mTOR (mammalian Target Of Rapamycin) inhibitor (IC₅₀ = 0.08 nM). Displays 75-fold selectivity over PI3Kα (IC₅₀ = 6 nM).
• CAS Number
  1062172-60-4
• Structure Available
  Yes
• Salt Form
  No
• Molecular Formula
  C₃₀H₃₄N₈O₅
• Molecular Weight
  586.64
• Cell Permeable
  Yes
• Purity
  ≥98% by HPLC
• Solubilities
  DMSO (>60 mg/ml)
• Handling
  Protect from light and moisture
• Tag Line
  A selective, picomolar-potent mTOR inhibitor
• Storage Condition
  -20°C
• Shipping Condition
  gel pack
• Shelf Life
  24 months
• PubChem CID
  24936050
• PubChem CID Link
• SMILES
  COC(=O)N1CCC(CC1)N2C3=C(C=N2)C(=NC(=N3)C4=CC=C(C=C4)NC(=O)NC5=CC=C(C=C5)CO)N6CCOCC6
• InChi
  InChI=1S/C30H34N8O5/c1-42-30(41)37-12-10-24(11-13-37)38-28-25(18-31-38)27(36-14-16-43-17-15-36)34-26(35-28)21-4-8-23(9-5-21)33-29(40)32-22-6-2-20(19-39)3-7-22/h2-9,18,24,39H,10-17,19H2,1H3,(H2,32,33,40)
• InChi Key
  DLIGFKRUAOAIBA-UHFFFAOYSA-N
• Data Sheet Link
• MSDS Available
  Yes
• Additional description
  Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.

• Gene target
  mTOR   Inhibitor   WYE-28  
• Gene symbol
  IGHV4-28, SNORD114-28, RNVU1-28, SNORD115-28, SNORD116-28, ERVW-28, ERVK-28, IGKV2-28, IGHVII-28-1, IGKV2D-28
• Short name
  mTOR Inhibitor, WYE-28
• Alternative name
  Mammalian target on rapamycin suppressor, WYE-28
• Alternative to gene target
  mechanistic target of rapamycin (serine/threonine kinase), FRAP and FRAP1 and FRAP2 and RAFT1 and RAPT1, MTOR and IDBG-89258 and ENSG00000198793 and 2475, transferase activity, nuclei, Mtor and IDBG-204403 and ENSMUSG00000028991 and 56717, MTOR and IDBG-632731 and ENSBTAG00000015325 and 100139219

Gene info

• Identity
  HGNC:5645
• Gene
  IGHV4-28
• Long gene name
  immunoglobulin heavy variable 4-28
• GenBank acession
  • X05714
• Locus
  14q32.33
• Discovery year
  2000-04-04
• Entrez gene record
  28400
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152062

Gene info

• Identity
  HGNC:33016
• Gene
  SNORD114-28
• Long gene name
  small nucleolar RNA, C/D box 114-28
• Synonyms
  • 14q(II-28)
• Locus
  14q32.31
• Discovery year
  2006-09-26
• Entrez gene record
  767609
• Pubmed identfication
  • 12045206
• RefSeq identity
  • NR_003221.1
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:54432
• Gene
  RNVU1-28
• Long gene name
  RNA, variant U1 small nuclear 28
• Locus
  1q21.1
• Discovery year
  2019-07-26
• Classification
  • Variant U1 small nuclear RNAs

Gene info

• Identity
  HGNC:33047
• Gene
  SNORD115-28
• Long gene name
  small nucleolar RNA, C/D box 115-28
• Synonyms
  • HBII-52-28
• Locus
  15q11.2
• Discovery year
  2011-08-22
• Entrez gene record
  100036565
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003497
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:33347
• Gene
  SNORD116-28
• Long gene name
  small nucleolar RNA, C/D box 116-28
• Synonyms
  • HBII-85-28
• GenBank acession
  • AF250841
• Locus
  15q11.2
• Discovery year
  2007-02-16
• Entrez gene record
  100033820
• Pubmed identfication
  • 11106375
  • 11726556
• RefSeq identity
  • NR_003361
• Classification
  • Small nucleolar RNAs, C/D box

Gene info

• Identity
  HGNC:49316
• Gene
  ERVW-28
• Long gene name
  endogenous retrovirus group W member 28
• Synonyms gene name
  • endogenous retrovirus group W, member 28
• GenBank acession
  • HG421041
• Locus
  17q12b
• Discovery year
  2013-10-21

Gene info

• Identity
  HGNC:44981
• Gene
  ERVK-28
• Long gene name
  endogenous retrovirus group K member 28
• Synonyms gene name
  • endogenous retrovirus group K, member 28
• GenBank acession
  • JZ164911
• Locus
  19q11
• Discovery year
  2014-01-03
• Pubmed identfication
  • 23338945
• VEGA ID
  OTTHUMG00000180737

Gene info

• Identity
  HGNC:5783
• Gene
  IGKV2-28
• Long gene name
  immunoglobulin kappa variable 2-28
• GenBank acession
  • X63397
• Locus
  2p11.2
• Discovery year
  2000-04-18
• Entrez gene record
  28921
• RefSeq identity
  • NG_000834
• Classification
  • Immunoglobulin kappa locus at 2p11.2
• VEGA ID
  OTTHUMG00000151652

Gene info

• Identity
  HGNC:5675
• Gene
  IGHVII-28-1
• Long gene name
  immunoglobulin heavy variable (II)-28-1 (pseudogene)
• Synonyms gene name
  • immunoglobulin heavy variable (II)-28-1
  • immunoglobulin heavy variable (II)-28-1 pseudogene
• Synonyms
  • IGHV(II)-28-1
• GenBank acession
  • AB019439
• Locus
  14q32.33
• Discovery year
  2000-04-17
• Entrez gene record
  28372
• RefSeq identity
  • NG_001019
• Classification
  • Immunoglobulin heavy locus at 14q32.33
• VEGA ID
  OTTHUMG00000152101

Gene info

• Identity
  HGNC:5799
• Gene
  IGKV2D-28
• Long gene name
  immunoglobulin kappa variable 2D-28
• GenBank acession
  • X12691
• Locus
  2p11.2
• Discovery year
  2000-04-18
• Entrez gene record
  28883
• RefSeq identity
  • NG_000833
• Classification
  • Immunoglobulin kappa locus at 2p11.2
• VEGA ID
  OTTHUMG00000151616

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