Jumonji HDM Inhibitor, JIB-04
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Catalog number
2474-25
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Price
Please ask
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Size
25 mg
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Alternative_name
5-Chloro-2-[(E)-2-[phenyl(pyridin-2-yl)methylidene]hydrazin-1-yl]pyridine; NSC693627
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Description
JIB-04 (E-isomer) is a potent, cell-permeable inhibitor of Jumonji histone demethylases in vitro and in vivo. (In vitro IC₅₀ values are 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively). JIB-04 is not a competitive inhibitor of α-ketoglutarate ; it selectively inhibits viability of several human cancer cell lines with little toxicity towards normal cells, and also diminishes tumor growth in xenograft mouse models.
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CAS Number
199596-05-9
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Structure Available
Yes
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Salt Form
No
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Molecular Formula
C₁₇H₁₃ClN₄
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Molecular Weight
308.76
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Cell Permeable
Yes
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Purity
≥98% by HPLC
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Solubilities
DMSO (~20 mg/ml)
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Handling
Protect from air and light
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Tag Line
A potent jumonji HDM inhibitor
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Storage Condition
-20°C
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Shipping Condition
gel pack
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Shelf Life
24 months
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PubChem CID
6519698
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SMILES
C1=CC=C(C=C1)C(=NNC2=NC=C(C=C2)Cl)C3=CC=CC=N3
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InChi
InChI=1S/C17H13ClN4/c18-14-9-10-16(20-12-14)21-22-17(13-6-2-1-3-7-13)15-8-4-5-11-19-15/h1-12H,(H,20,21)/b22-17+
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InChi Key
YHHFKWKMXWRVTJ-OQKWZONESA-N
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MSDS Available
Yes
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Additional description
Tissue, pathway, proteinase, peptidase, protease ,acrosin, lipoprotein, activator, caspase, trypsin, papain, esterase inhibitors are proteins or receptor ligands or receptor antagonists that bind to an enzyme receptor and decreases its activity. Since blocking an enzyme's activity can kill a pathogen or correct a metabolic imbalance, many drugs are enzyme inhibitors. Not all receptor antagonist that bind to enzymes are inhibitors; enzyme activator ligands or agonists bind to enzymes and increase their enzymatic activity, while enzyme substrates bind and are converted to products in the normal catalytic cycle of the enzyme.
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Gene target
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Gene symbol
YARS2, HCG4P4
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Short name
Jumonji HDM Inhibitor, JIB-04
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Alternative name
Jumonji HDM suppressor, JIB-04
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Gene info
Gene info
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